Non-Random mtDNA Segregation Patterns Indicate a Metastable Heteroplasmic Segregation Unit in m.3243A>G Cybrid Cells

Many pathogenic mitochondrial DNA mutations are heteroplasmic, with a mixture of mutated and wild-type mtDNA present within individual cells. The severity and extent of the clinical phenotype is largely due to the distribution of mutated molecules between cells in different tissues, but mechanisms u...

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Detalles Bibliográficos
Autores principales: Raap, Anton K., Jahangir Tafrechi, Roshan S., van de Rijke, Frans M., Pyle, Angela, Wählby, Carolina, Szuhai, Karoly, Ravelli, Raimond B. G., de Coo, René F. M., Rajasimha, Harsha K., Nilsson, Mats, Chinnery, Patrick F., Samuels, David C., Janssen, George M. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525564/
https://www.ncbi.nlm.nih.gov/pubmed/23272214
http://dx.doi.org/10.1371/journal.pone.0052080

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