The Natively Disordered Loop of Bcl-2 Undergoes Phosphorylation-Dependent Conformational Change and Interacts with Pin1

Bcl-2 plays a central role in the regulation of apoptosis. Structural studies of Bcl-2 revealed the presence of a flexible and natively disordered loop that bridges the Bcl-2 homology motifs, BH3 and BH4. This loop is phosphorylated on multiple sites in response to a variety of external stimuli, inc...

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Detalles Bibliográficos
Autores principales: Kang, CongBao, Bharatham, Nagakumar, Chia, Joel, Mu, Yuguang, Baek, Kwanghee, Yoon, Ho Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525568/
https://www.ncbi.nlm.nih.gov/pubmed/23272207
http://dx.doi.org/10.1371/journal.pone.0052047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525568/
https://www.ncbi.nlm.nih.gov/pubmed/23272207
http://dx.doi.org/10.1371/journal.pone.0052047

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