Senescence and NFκB: A trojan horse in tumors?

The induction of senescence in tumor cells impairs transformation and promotes an anticancer immune response resulting from the production by senescent cells of cytokines and chemokines, an aspect known as “senescence-associated secretory phenotype” (SASP). Here we discuss recent findings regarding...

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Detalles Bibliográficos
Autores principales: Crescenzi, Elvira, De Palma, Raffaele, Leonardi, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525614/
https://www.ncbi.nlm.nih.gov/pubmed/23264905
http://dx.doi.org/10.4161/onci.22525
Descripción
Sumario:The induction of senescence in tumor cells impairs transformation and promotes an anticancer immune response resulting from the production by senescent cells of cytokines and chemokines, an aspect known as “senescence-associated secretory phenotype” (SASP). Here we discuss recent findings regarding the role of NFκB in the modulation of the SASP and the consequent anticancer immune response.

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