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Modulating CD27 signaling to treat cancer
CD27 signaling can either improve T-cell function or lead to T-cell dysfunction, depending on the duration and conditions of receptor ligation. Recent studies have shown that modulating the CD70-CD27 interaction is an attractive strategy to treat solid tumors and also to directly target leukemia ste...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525617/ https://www.ncbi.nlm.nih.gov/pubmed/23264908 http://dx.doi.org/10.4161/onci.21425 |
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author | Riether, Carsten Schürch, Christian Ochsenbein, Adrian F. |
author_facet | Riether, Carsten Schürch, Christian Ochsenbein, Adrian F. |
author_sort | Riether, Carsten |
collection | PubMed |
description | CD27 signaling can either improve T-cell function or lead to T-cell dysfunction, depending on the duration and conditions of receptor ligation. Recent studies have shown that modulating the CD70-CD27 interaction is an attractive strategy to treat solid tumors and also to directly target leukemia stem cells. |
format | Online Article Text |
id | pubmed-3525617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-35256172012-12-21 Modulating CD27 signaling to treat cancer Riether, Carsten Schürch, Christian Ochsenbein, Adrian F. Oncoimmunology Author's View CD27 signaling can either improve T-cell function or lead to T-cell dysfunction, depending on the duration and conditions of receptor ligation. Recent studies have shown that modulating the CD70-CD27 interaction is an attractive strategy to treat solid tumors and also to directly target leukemia stem cells. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525617/ /pubmed/23264908 http://dx.doi.org/10.4161/onci.21425 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Author's View Riether, Carsten Schürch, Christian Ochsenbein, Adrian F. Modulating CD27 signaling to treat cancer |
title | Modulating CD27 signaling to treat cancer |
title_full | Modulating CD27 signaling to treat cancer |
title_fullStr | Modulating CD27 signaling to treat cancer |
title_full_unstemmed | Modulating CD27 signaling to treat cancer |
title_short | Modulating CD27 signaling to treat cancer |
title_sort | modulating cd27 signaling to treat cancer |
topic | Author's View |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525617/ https://www.ncbi.nlm.nih.gov/pubmed/23264908 http://dx.doi.org/10.4161/onci.21425 |
work_keys_str_mv | AT riethercarsten modulatingcd27signalingtotreatcancer AT schurchchristian modulatingcd27signalingtotreatcancer AT ochsenbeinadrianf modulatingcd27signalingtotreatcancer |