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Modulating CD27 signaling to treat cancer

CD27 signaling can either improve T-cell function or lead to T-cell dysfunction, depending on the duration and conditions of receptor ligation. Recent studies have shown that modulating the CD70-CD27 interaction is an attractive strategy to treat solid tumors and also to directly target leukemia ste...

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Detalles Bibliográficos
Autores principales: Riether, Carsten, Schürch, Christian, Ochsenbein, Adrian F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525617/
https://www.ncbi.nlm.nih.gov/pubmed/23264908
http://dx.doi.org/10.4161/onci.21425
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author Riether, Carsten
Schürch, Christian
Ochsenbein, Adrian F.
author_facet Riether, Carsten
Schürch, Christian
Ochsenbein, Adrian F.
author_sort Riether, Carsten
collection PubMed
description CD27 signaling can either improve T-cell function or lead to T-cell dysfunction, depending on the duration and conditions of receptor ligation. Recent studies have shown that modulating the CD70-CD27 interaction is an attractive strategy to treat solid tumors and also to directly target leukemia stem cells.
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spelling pubmed-35256172012-12-21 Modulating CD27 signaling to treat cancer Riether, Carsten Schürch, Christian Ochsenbein, Adrian F. Oncoimmunology Author's View CD27 signaling can either improve T-cell function or lead to T-cell dysfunction, depending on the duration and conditions of receptor ligation. Recent studies have shown that modulating the CD70-CD27 interaction is an attractive strategy to treat solid tumors and also to directly target leukemia stem cells. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525617/ /pubmed/23264908 http://dx.doi.org/10.4161/onci.21425 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Riether, Carsten
Schürch, Christian
Ochsenbein, Adrian F.
Modulating CD27 signaling to treat cancer
title Modulating CD27 signaling to treat cancer
title_full Modulating CD27 signaling to treat cancer
title_fullStr Modulating CD27 signaling to treat cancer
title_full_unstemmed Modulating CD27 signaling to treat cancer
title_short Modulating CD27 signaling to treat cancer
title_sort modulating cd27 signaling to treat cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525617/
https://www.ncbi.nlm.nih.gov/pubmed/23264908
http://dx.doi.org/10.4161/onci.21425
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