Tumor-infiltrating B cells and T cells: Working together to promote patient survival

We recently reported a novel cooperative relationship between tumor-infiltrating B cells and CD8(+) T cells in ovarian cancer, leading to increased patient survival. Here, we discuss the mechanisms whereby B cells might enhance cellular immunity, including serving as antigen-presenting cells, organi...

Descripción completa

Detalles Bibliográficos
Autores principales: Nielsen, Julie S., Nelson, Brad H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525624/
https://www.ncbi.nlm.nih.gov/pubmed/23264915
http://dx.doi.org/10.4161/onci.21650
_version_ 1782253450301538304
author Nielsen, Julie S.
Nelson, Brad H.
author_facet Nielsen, Julie S.
Nelson, Brad H.
author_sort Nielsen, Julie S.
collection PubMed
description We recently reported a novel cooperative relationship between tumor-infiltrating B cells and CD8(+) T cells in ovarian cancer, leading to increased patient survival. Here, we discuss the mechanisms whereby B cells might enhance cellular immunity, including serving as antigen-presenting cells, organizing tertiary lymphoid structures and secreting polarizing cytokines. The enhancement of both B and T-cell responses may result in more potent and sustained antitumor immunity.
format Online
Article
Text
id pubmed-3525624
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-35256242012-12-21 Tumor-infiltrating B cells and T cells: Working together to promote patient survival Nielsen, Julie S. Nelson, Brad H. Oncoimmunology Author's View We recently reported a novel cooperative relationship between tumor-infiltrating B cells and CD8(+) T cells in ovarian cancer, leading to increased patient survival. Here, we discuss the mechanisms whereby B cells might enhance cellular immunity, including serving as antigen-presenting cells, organizing tertiary lymphoid structures and secreting polarizing cytokines. The enhancement of both B and T-cell responses may result in more potent and sustained antitumor immunity. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525624/ /pubmed/23264915 http://dx.doi.org/10.4161/onci.21650 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Nielsen, Julie S.
Nelson, Brad H.
Tumor-infiltrating B cells and T cells: Working together to promote patient survival
title Tumor-infiltrating B cells and T cells: Working together to promote patient survival
title_full Tumor-infiltrating B cells and T cells: Working together to promote patient survival
title_fullStr Tumor-infiltrating B cells and T cells: Working together to promote patient survival
title_full_unstemmed Tumor-infiltrating B cells and T cells: Working together to promote patient survival
title_short Tumor-infiltrating B cells and T cells: Working together to promote patient survival
title_sort tumor-infiltrating b cells and t cells: working together to promote patient survival
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525624/
https://www.ncbi.nlm.nih.gov/pubmed/23264915
http://dx.doi.org/10.4161/onci.21650
work_keys_str_mv AT nielsenjulies tumorinfiltratingbcellsandtcellsworkingtogethertopromotepatientsurvival
AT nelsonbradh tumorinfiltratingbcellsandtcellsworkingtogethertopromotepatientsurvival

Ejemplares similares