Chemoimmunotherapy for advanced gastrointestinal carcinomas: A successful combination of gene therapy and cyclophosphamide

The combination of a single low dose of cyclophosphamide (Cy) with the adenovirus-mediated gene transfer of interleukin-12 (AdIL-12) might represent a successful therapy for experimental gastrointestinal tumors. This approach has been proven to revert immunosuppressive mechanisms elicited by cancer...

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Autores principales: Malvicini, Mariana, Piccioni, Flavia, Bayo, Juan, Fiore, Esteban, Atorrasagasti, Catalina, Alaniz, Laura, Garcia, Mariana, Aquino, Jorge B., Gidekel, Manuel, Matar, Pablo, Mazzolini, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525625/
https://www.ncbi.nlm.nih.gov/pubmed/23264916
http://dx.doi.org/10.4161/onci.21651
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author Malvicini, Mariana
Piccioni, Flavia
Bayo, Juan
Fiore, Esteban
Atorrasagasti, Catalina
Alaniz, Laura
Garcia, Mariana
Aquino, Jorge B.
Gidekel, Manuel
Matar, Pablo
Mazzolini, Guillermo
author_facet Malvicini, Mariana
Piccioni, Flavia
Bayo, Juan
Fiore, Esteban
Atorrasagasti, Catalina
Alaniz, Laura
Garcia, Mariana
Aquino, Jorge B.
Gidekel, Manuel
Matar, Pablo
Mazzolini, Guillermo
author_sort Malvicini, Mariana
collection PubMed
description The combination of a single low dose of cyclophosphamide (Cy) with the adenovirus-mediated gene transfer of interleukin-12 (AdIL-12) might represent a successful therapy for experimental gastrointestinal tumors. This approach has been proven to revert immunosuppressive mechanisms elicited by cancer cells and to synergistically promote antitumor immunity. In addition, this therapeutic regimen has been shown to be more efficient in achieving complete tumor regressions in mice than the application of a metronomic schedule of Cy plus AdIL-12.
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spelling pubmed-35256252012-12-21 Chemoimmunotherapy for advanced gastrointestinal carcinomas: A successful combination of gene therapy and cyclophosphamide Malvicini, Mariana Piccioni, Flavia Bayo, Juan Fiore, Esteban Atorrasagasti, Catalina Alaniz, Laura Garcia, Mariana Aquino, Jorge B. Gidekel, Manuel Matar, Pablo Mazzolini, Guillermo Oncoimmunology Author's View The combination of a single low dose of cyclophosphamide (Cy) with the adenovirus-mediated gene transfer of interleukin-12 (AdIL-12) might represent a successful therapy for experimental gastrointestinal tumors. This approach has been proven to revert immunosuppressive mechanisms elicited by cancer cells and to synergistically promote antitumor immunity. In addition, this therapeutic regimen has been shown to be more efficient in achieving complete tumor regressions in mice than the application of a metronomic schedule of Cy plus AdIL-12. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525625/ /pubmed/23264916 http://dx.doi.org/10.4161/onci.21651 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Malvicini, Mariana
Piccioni, Flavia
Bayo, Juan
Fiore, Esteban
Atorrasagasti, Catalina
Alaniz, Laura
Garcia, Mariana
Aquino, Jorge B.
Gidekel, Manuel
Matar, Pablo
Mazzolini, Guillermo
Chemoimmunotherapy for advanced gastrointestinal carcinomas: A successful combination of gene therapy and cyclophosphamide
title Chemoimmunotherapy for advanced gastrointestinal carcinomas: A successful combination of gene therapy and cyclophosphamide
title_full Chemoimmunotherapy for advanced gastrointestinal carcinomas: A successful combination of gene therapy and cyclophosphamide
title_fullStr Chemoimmunotherapy for advanced gastrointestinal carcinomas: A successful combination of gene therapy and cyclophosphamide
title_full_unstemmed Chemoimmunotherapy for advanced gastrointestinal carcinomas: A successful combination of gene therapy and cyclophosphamide
title_short Chemoimmunotherapy for advanced gastrointestinal carcinomas: A successful combination of gene therapy and cyclophosphamide
title_sort chemoimmunotherapy for advanced gastrointestinal carcinomas: a successful combination of gene therapy and cyclophosphamide
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525625/
https://www.ncbi.nlm.nih.gov/pubmed/23264916
http://dx.doi.org/10.4161/onci.21651
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