Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies

The development and use of combination immunotherapy-based anticancer regimens is at an early but clearly exciting stage. We now demonstrate that the antibody-based co-targeting of multiple immunostimulatory and/or inhibitory pathways can be used safely and effectively in combination with single dos...

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Autores principales: Verbrugge, Inge, Galli, Mara, Smyth, Mark J., Johnstone, Ricky W., Haynes, Nicole M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525626/
https://www.ncbi.nlm.nih.gov/pubmed/23264917
http://dx.doi.org/10.4161/onci.21652
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author Verbrugge, Inge
Galli, Mara
Smyth, Mark J.
Johnstone, Ricky W.
Haynes, Nicole M.
author_facet Verbrugge, Inge
Galli, Mara
Smyth, Mark J.
Johnstone, Ricky W.
Haynes, Nicole M.
author_sort Verbrugge, Inge
collection PubMed
description The development and use of combination immunotherapy-based anticancer regimens is at an early but clearly exciting stage. We now demonstrate that the antibody-based co-targeting of multiple immunostimulatory and/or inhibitory pathways can be used safely and effectively in combination with single dose or fractionated radiotherapy to cure mice bearing established mammary tumors.
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spelling pubmed-35256262012-12-21 Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies Verbrugge, Inge Galli, Mara Smyth, Mark J. Johnstone, Ricky W. Haynes, Nicole M. Oncoimmunology Author's View The development and use of combination immunotherapy-based anticancer regimens is at an early but clearly exciting stage. We now demonstrate that the antibody-based co-targeting of multiple immunostimulatory and/or inhibitory pathways can be used safely and effectively in combination with single dose or fractionated radiotherapy to cure mice bearing established mammary tumors. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525626/ /pubmed/23264917 http://dx.doi.org/10.4161/onci.21652 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Verbrugge, Inge
Galli, Mara
Smyth, Mark J.
Johnstone, Ricky W.
Haynes, Nicole M.
Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies
title Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies
title_full Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies
title_fullStr Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies
title_full_unstemmed Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies
title_short Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies
title_sort enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525626/
https://www.ncbi.nlm.nih.gov/pubmed/23264917
http://dx.doi.org/10.4161/onci.21652
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