Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment

We identified novel mechanisms whereby TIM-3 suppresses innate immunity as induced by nucleic acids. Interaction of TIM-3 with HMGB1 inhibits the recruitment of nucleic acids to the endosomal compartment of dendritic cells, impairing the transduction of innate immune signals. Thus, TIM-3 is an effec...

Descripción completa

Detalles Bibliográficos
Autor principal: Jinushi, Masahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525627/
https://www.ncbi.nlm.nih.gov/pubmed/23264918
http://dx.doi.org/10.4161/onci.21681
_version_ 1782253450979966976
author Jinushi, Masahisa
author_facet Jinushi, Masahisa
author_sort Jinushi, Masahisa
collection PubMed
description We identified novel mechanisms whereby TIM-3 suppresses innate immunity as induced by nucleic acids. Interaction of TIM-3 with HMGB1 inhibits the recruitment of nucleic acids to the endosomal compartment of dendritic cells, impairing the transduction of innate immune signals. Thus, TIM-3 is an effective target for enhancing the immunogenicity of nucleic acids in the context of cancer therapy.
format Online
Article
Text
id pubmed-3525627
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-35256272012-12-21 Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment Jinushi, Masahisa Oncoimmunology Author's View We identified novel mechanisms whereby TIM-3 suppresses innate immunity as induced by nucleic acids. Interaction of TIM-3 with HMGB1 inhibits the recruitment of nucleic acids to the endosomal compartment of dendritic cells, impairing the transduction of innate immune signals. Thus, TIM-3 is an effective target for enhancing the immunogenicity of nucleic acids in the context of cancer therapy. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525627/ /pubmed/23264918 http://dx.doi.org/10.4161/onci.21681 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Jinushi, Masahisa
Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment
title Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment
title_full Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment
title_fullStr Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment
title_full_unstemmed Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment
title_short Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment
title_sort regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525627/
https://www.ncbi.nlm.nih.gov/pubmed/23264918
http://dx.doi.org/10.4161/onci.21681
work_keys_str_mv AT jinushimasahisa regulatorymechanismsofnucleicacidmediatedinnateimmuneresponsesinthetumormicroenvironment

Ejemplares similares