In vivo evidence for dendritic cell lysis by NK cells: Hints on improving cancer vaccines by targeting NK cell activation

By using an experimental model of anticancer vaccination, we have recently lent support to the assumption, so far only sustained by in vitro data, that natural killer cells can restrain less immunogenic, allegedly tolerogenic, dendritic cells (DCs). This in vivo selection of immunogenic DCs appears...

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Autor principal: Ferlazzo, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525628/
https://www.ncbi.nlm.nih.gov/pubmed/23264919
http://dx.doi.org/10.4161/onci.21682
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author Ferlazzo, Guido
author_facet Ferlazzo, Guido
author_sort Ferlazzo, Guido
collection PubMed
description By using an experimental model of anticancer vaccination, we have recently lent support to the assumption, so far only sustained by in vitro data, that natural killer cells can restrain less immunogenic, allegedly tolerogenic, dendritic cells (DCs). This in vivo selection of immunogenic DCs appears to depend on perforin and to be associated with a more protective tumor-specific T lymphocyte response.
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spelling pubmed-35256282012-12-21 In vivo evidence for dendritic cell lysis by NK cells: Hints on improving cancer vaccines by targeting NK cell activation Ferlazzo, Guido Oncoimmunology Author's View By using an experimental model of anticancer vaccination, we have recently lent support to the assumption, so far only sustained by in vitro data, that natural killer cells can restrain less immunogenic, allegedly tolerogenic, dendritic cells (DCs). This in vivo selection of immunogenic DCs appears to depend on perforin and to be associated with a more protective tumor-specific T lymphocyte response. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525628/ /pubmed/23264919 http://dx.doi.org/10.4161/onci.21682 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Ferlazzo, Guido
In vivo evidence for dendritic cell lysis by NK cells: Hints on improving cancer vaccines by targeting NK cell activation
title In vivo evidence for dendritic cell lysis by NK cells: Hints on improving cancer vaccines by targeting NK cell activation
title_full In vivo evidence for dendritic cell lysis by NK cells: Hints on improving cancer vaccines by targeting NK cell activation
title_fullStr In vivo evidence for dendritic cell lysis by NK cells: Hints on improving cancer vaccines by targeting NK cell activation
title_full_unstemmed In vivo evidence for dendritic cell lysis by NK cells: Hints on improving cancer vaccines by targeting NK cell activation
title_short In vivo evidence for dendritic cell lysis by NK cells: Hints on improving cancer vaccines by targeting NK cell activation
title_sort in vivo evidence for dendritic cell lysis by nk cells: hints on improving cancer vaccines by targeting nk cell activation
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525628/
https://www.ncbi.nlm.nih.gov/pubmed/23264919
http://dx.doi.org/10.4161/onci.21682
work_keys_str_mv AT ferlazzoguido invivoevidencefordendriticcelllysisbynkcellshintsonimprovingcancervaccinesbytargetingnkcellactivation

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