Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8(+) T cells

Successful cancer immunotherapy is thought to require de novo priming of tumor specific CD8(+) T cells in lymphatic organs. Contrasting these beliefs, cancer therapy based on interleukin-10 (IL-10) results in tumor rejection without a requirement for T-cell trafficking from lymphatic organs. Rather,...

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Detalles Bibliográficos
Autores principales: Emmerich, Jan, Mumm, John B., Oft, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525629/
https://www.ncbi.nlm.nih.gov/pubmed/23264920
http://dx.doi.org/10.4161/onci.21683
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author Emmerich, Jan
Mumm, John B.
Oft, Martin
author_facet Emmerich, Jan
Mumm, John B.
Oft, Martin
author_sort Emmerich, Jan
collection PubMed
description Successful cancer immunotherapy is thought to require de novo priming of tumor specific CD8(+) T cells in lymphatic organs. Contrasting these beliefs, cancer therapy based on interleukin-10 (IL-10) results in tumor rejection without a requirement for T-cell trafficking from lymphatic organs. Rather, IL-10 directly activates autochthonous, tumor-resident CD8(+) T cells.
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spelling pubmed-35256292012-12-21 Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8(+) T cells Emmerich, Jan Mumm, John B. Oft, Martin Oncoimmunology Author's View Successful cancer immunotherapy is thought to require de novo priming of tumor specific CD8(+) T cells in lymphatic organs. Contrasting these beliefs, cancer therapy based on interleukin-10 (IL-10) results in tumor rejection without a requirement for T-cell trafficking from lymphatic organs. Rather, IL-10 directly activates autochthonous, tumor-resident CD8(+) T cells. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525629/ /pubmed/23264920 http://dx.doi.org/10.4161/onci.21683 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Emmerich, Jan
Mumm, John B.
Oft, Martin
Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8(+) T cells
title Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8(+) T cells
title_full Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8(+) T cells
title_fullStr Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8(+) T cells
title_full_unstemmed Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8(+) T cells
title_short Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8(+) T cells
title_sort autochthonous t cells to the rescue: il-10 directly activates tumor-resident cd8(+) t cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525629/
https://www.ncbi.nlm.nih.gov/pubmed/23264920
http://dx.doi.org/10.4161/onci.21683
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