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Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8(+) T cells

Successful cancer immunotherapy is thought to require de novo priming of tumor specific CD8(+) T cells in lymphatic organs. Contrasting these beliefs, cancer therapy based on interleukin-10 (IL-10) results in tumor rejection without a requirement for T-cell trafficking from lymphatic organs. Rather,...

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Detalles Bibliográficos
Autores principales:	Emmerich, Jan, Mumm, John B., Oft, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2012
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525629/ https://www.ncbi.nlm.nih.gov/pubmed/23264920 http://dx.doi.org/10.4161/onci.21683

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