Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects

Retrospective clinical data indicate that cardiac glycosides (CGs), notably digoxin, prolong the survival of carcinoma patients treated with conventional chemotherapy. CGs are known to influence the immune response at multiple levels. In addition, recent results suggest that CGs trigger the immunoge...

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Autores principales: Kepp, Oliver, Menger, Laurie, Vacchelli, Erika, Adjemian, Sandy, Martins, Isabelle, Ma, Yuting, Sukkurwala, Abdul Qader, Michaud, Mickaël, Galluzzi, Lorenzo, Zitvogel, Laurence, Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525630/
https://www.ncbi.nlm.nih.gov/pubmed/23264921
http://dx.doi.org/10.4161/onci.21684
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author Kepp, Oliver
Menger, Laurie
Vacchelli, Erika
Adjemian, Sandy
Martins, Isabelle
Ma, Yuting
Sukkurwala, Abdul Qader
Michaud, Mickaël
Galluzzi, Lorenzo
Zitvogel, Laurence
Kroemer, Guido
author_facet Kepp, Oliver
Menger, Laurie
Vacchelli, Erika
Adjemian, Sandy
Martins, Isabelle
Ma, Yuting
Sukkurwala, Abdul Qader
Michaud, Mickaël
Galluzzi, Lorenzo
Zitvogel, Laurence
Kroemer, Guido
author_sort Kepp, Oliver
collection PubMed
description Retrospective clinical data indicate that cardiac glycosides (CGs), notably digoxin, prolong the survival of carcinoma patients treated with conventional chemotherapy. CGs are known to influence the immune response at multiple levels. In addition, recent results suggest that CGs trigger the immunogenic demise of cancer cells, an effect that most likely contributes to their clinical anticancer activity.
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spelling pubmed-35256302012-12-21 Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects Kepp, Oliver Menger, Laurie Vacchelli, Erika Adjemian, Sandy Martins, Isabelle Ma, Yuting Sukkurwala, Abdul Qader Michaud, Mickaël Galluzzi, Lorenzo Zitvogel, Laurence Kroemer, Guido Oncoimmunology Author's View Retrospective clinical data indicate that cardiac glycosides (CGs), notably digoxin, prolong the survival of carcinoma patients treated with conventional chemotherapy. CGs are known to influence the immune response at multiple levels. In addition, recent results suggest that CGs trigger the immunogenic demise of cancer cells, an effect that most likely contributes to their clinical anticancer activity. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525630/ /pubmed/23264921 http://dx.doi.org/10.4161/onci.21684 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Kepp, Oliver
Menger, Laurie
Vacchelli, Erika
Adjemian, Sandy
Martins, Isabelle
Ma, Yuting
Sukkurwala, Abdul Qader
Michaud, Mickaël
Galluzzi, Lorenzo
Zitvogel, Laurence
Kroemer, Guido
Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects
title Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects
title_full Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects
title_fullStr Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects
title_full_unstemmed Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects
title_short Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects
title_sort anticancer activity of cardiac glycosides: at the frontier between cell-autonomous and immunological effects
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525630/
https://www.ncbi.nlm.nih.gov/pubmed/23264921
http://dx.doi.org/10.4161/onci.21684
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