High-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them

The adoptive transfer of lymphocytes expressing high-avidity T-cell receptors with antitumor specificity provides a promising therapy for cancer patients. Recently, we compared 12 HLA-A2-restricted, tyrosinase peptide-specific CD8(+) cytotoxic T-lymphocyte (CTL) clones and demonstrated that polyfunc...

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Detalles Bibliográficos
Autores principales: Wilde, Susanne, Schendel, Dolores J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525631/
https://www.ncbi.nlm.nih.gov/pubmed/23264922
http://dx.doi.org/10.4161/onci.21717
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author Wilde, Susanne
Schendel, Dolores J.
author_facet Wilde, Susanne
Schendel, Dolores J.
author_sort Wilde, Susanne
collection PubMed
description The adoptive transfer of lymphocytes expressing high-avidity T-cell receptors with antitumor specificity provides a promising therapy for cancer patients. Recently, we compared 12 HLA-A2-restricted, tyrosinase peptide-specific CD8(+) cytotoxic T-lymphocyte (CTL) clones and demonstrated that polyfunctional type 1 helper (Th1)-cytokine secretion serves to rapidly select high-quality, high-avidity CTLs.
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spelling pubmed-35256312012-12-21 High-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them Wilde, Susanne Schendel, Dolores J. Oncoimmunology Author's View The adoptive transfer of lymphocytes expressing high-avidity T-cell receptors with antitumor specificity provides a promising therapy for cancer patients. Recently, we compared 12 HLA-A2-restricted, tyrosinase peptide-specific CD8(+) cytotoxic T-lymphocyte (CTL) clones and demonstrated that polyfunctional type 1 helper (Th1)-cytokine secretion serves to rapidly select high-quality, high-avidity CTLs. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525631/ /pubmed/23264922 http://dx.doi.org/10.4161/onci.21717 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Wilde, Susanne
Schendel, Dolores J.
High-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them
title High-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them
title_full High-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them
title_fullStr High-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them
title_full_unstemmed High-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them
title_short High-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them
title_sort high-quality and high-avidity t cell clones specific for tumor-associated antigens and how to find them
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525631/
https://www.ncbi.nlm.nih.gov/pubmed/23264922
http://dx.doi.org/10.4161/onci.21717
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AT schendeldoloresj highqualityandhighaviditytcellclonesspecificfortumorassociatedantigensandhowtofindthem

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