Targeting MDSCs enhance therapeutic vaccination responses against lung cancer

Myeloid-derived suppressor cells (MDSCs) are important regulators of immune responses. These cells suppress the cytotoxic activities of natural killer (NK)-cell and T-cell effectors and promote tumor growth. We demonstrated that depleting MDSCs improve therapeutic responses to vaccination in a murin...

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Detalles Bibliográficos
Autores principales: Srivastava, Minu K., Dubinett, Steven, Sharma, Sherven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525634/
https://www.ncbi.nlm.nih.gov/pubmed/23264925
http://dx.doi.org/10.4161/onci.21970
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author Srivastava, Minu K.
Dubinett, Steven
Sharma, Sherven
author_facet Srivastava, Minu K.
Dubinett, Steven
Sharma, Sherven
author_sort Srivastava, Minu K.
collection PubMed
description Myeloid-derived suppressor cells (MDSCs) are important regulators of immune responses. These cells suppress the cytotoxic activities of natural killer (NK)-cell and T-cell effectors and promote tumor growth. We demonstrated that depleting MDSCs improve therapeutic responses to vaccination in a murine model of lung cancer. This approach may prove beneficial against tumors in which MDSC exert prominent immunosuppressive effects.
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spelling pubmed-35256342012-12-21 Targeting MDSCs enhance therapeutic vaccination responses against lung cancer Srivastava, Minu K. Dubinett, Steven Sharma, Sherven Oncoimmunology Author's View Myeloid-derived suppressor cells (MDSCs) are important regulators of immune responses. These cells suppress the cytotoxic activities of natural killer (NK)-cell and T-cell effectors and promote tumor growth. We demonstrated that depleting MDSCs improve therapeutic responses to vaccination in a murine model of lung cancer. This approach may prove beneficial against tumors in which MDSC exert prominent immunosuppressive effects. Landes Bioscience 2012-12-01 /pmc/articles/PMC3525634/ /pubmed/23264925 http://dx.doi.org/10.4161/onci.21970 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Srivastava, Minu K.
Dubinett, Steven
Sharma, Sherven
Targeting MDSCs enhance therapeutic vaccination responses against lung cancer
title Targeting MDSCs enhance therapeutic vaccination responses against lung cancer
title_full Targeting MDSCs enhance therapeutic vaccination responses against lung cancer
title_fullStr Targeting MDSCs enhance therapeutic vaccination responses against lung cancer
title_full_unstemmed Targeting MDSCs enhance therapeutic vaccination responses against lung cancer
title_short Targeting MDSCs enhance therapeutic vaccination responses against lung cancer
title_sort targeting mdscs enhance therapeutic vaccination responses against lung cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525634/
https://www.ncbi.nlm.nih.gov/pubmed/23264925
http://dx.doi.org/10.4161/onci.21970
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