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Melatonin Protects against Apoptosis-Inducing Factor (AIF)-Dependent Cell Death during Acetaminophen-Induced Acute Liver Failure

Acetaminophen (APAP) overdose is the most frequent cause of acute liver failure and is primarily caused by cytochrome P450 (CYP) 2E1-driven conversion of APAP into hepatotoxic metabolites. Several reports showed that melatonin attenuated APAP-induced acute liver failure. Nevertheless, the exact mech...

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Detalles Bibliográficos
Autores principales:	Liang, Ying-Li, Zhang, Zhi-Hui, Liu, Xiao-Jing, Liu, Xiao-Qian, Tao, Li, Zhang, Ye-Fa, Wang, Hua, Zhang, Cheng, Chen, Xi, Xu, De-Xiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525654/ https://www.ncbi.nlm.nih.gov/pubmed/23272189 http://dx.doi.org/10.1371/journal.pone.0051911

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