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Promoter Methylation Analysis of IDH Genes in Human Gliomas

Mutations in isocitrate dehydrogenase (IDH)-1 or -2 are found in the majority of WHO grade II and III astrocytomas and oligodendrogliomas, and secondary glioblastomas. Almost all described mutations are heterozygous missense mutations affecting a conserved arginine residue in the substrate binding s...

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Detalles Bibliográficos
Autores principales:	Flanagan, Simon, Lee, Maggie, Li, Cheryl C. Y., Suter, Catherine M., Buckland, Michael E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2012
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525876/ https://www.ncbi.nlm.nih.gov/pubmed/23267435 http://dx.doi.org/10.3389/fonc.2012.00193

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