PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

Parkinson's disease genes PINK1 and parkin encode kinase and ubiquitin ligase, respectively. The gene products PINK1 and Parkin are implicated in mitochondrial autophagy, or mitophagy. Upon the loss of mitochondrial membrane potential (ΔΨm), cytosolic Parkin is recruited to the mitochondria by...

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Detalles Bibliográficos
Autores principales: Shiba-Fukushima, Kahori, Imai, Yuzuru, Yoshida, Shigeharu, Ishihama, Yasushi, Kanao, Tomoko, Sato, Shigeto, Hattori, Nobutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525937/
https://www.ncbi.nlm.nih.gov/pubmed/23256036
http://dx.doi.org/10.1038/srep01002

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