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Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe

Human serum transferrin (hTF) binds Fe(III) tightly but reversibly, and delivers it to cells via a receptor-mediated endocytosis process. The metal-binding and release result in significant conformational changes of the protein. Here, we report the crystal structures of diferric-hTF (Fe(N)Fe(C)-hTF)...

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Detalles Bibliográficos
Autores principales:	Yang, Nan, Zhang, Hongmin, Wang, Minji, Hao, Quan, Sun, Hongzhe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525939/ https://www.ncbi.nlm.nih.gov/pubmed/23256035 http://dx.doi.org/10.1038/srep00999

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