Identification of Selective Inhibitors of the Potassium Channel Kv1.1–1.2((3)) by High-Throughput Virtual Screening and Automated Patch Clamp

ABSTRACT: Two voltage-dependent potassium channels, Kv1.1 (KCNA1) and Kv1.2 (KCNA2), are found to co-localize at the juxtaparanodal region of axons throughout the nervous system and are known to co-assemble in heteromultimeric channels, most likely in the form of the concatemer Kv1.1–1.2((3)). Loss...

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Detalles Bibliográficos
Autores principales: Wacker, Sören J, Jurkowski, Wiktor, Simmons, Katie J, Fishwick, Colin W G, Johnson, A Peter, Madge, David, Lindahl, Erik, Rolland, Jean-Francois, de Groot, Bert L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
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Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525944/
https://www.ncbi.nlm.nih.gov/pubmed/22473914
http://dx.doi.org/10.1002/cmdc.201100600

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