Per2 Mutation Recapitulates the Vascular Phenotype of Diabetes in the Retina and Bone Marrow

In this study, we assessed whether Per2 clock gene–mutant mice exhibit a vascular phenotype similar to diabetes. Per2 (B6.129-Per2(tm1Drw)/J) or wild-type control mice 4 and 12 months of age were used. To evaluate diabetes-like phenotype in Per2 mutant mice, retina was quantified for mRNA expression...

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Detalles Bibliográficos
Autores principales: Bhatwadekar, Ashay D., Yan, Yuanqing, Qi, Xiaoping, Thinschmidt, Jeffrey S., Neu, Matthew B., Li Calzi, Sergio, Shaw, Lynn C., Dominiguez, James M., Busik, Julia V., Lee, Choogon, Boulton, Michael E., Grant, Maria B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526035/
https://www.ncbi.nlm.nih.gov/pubmed/23193187
http://dx.doi.org/10.2337/db12-0172

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