Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature

Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient re...

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Autores principales: Otero, Luize, de Souza, Daiane Correa, de Cássia Tavares, Rita, Gomes, Bernadete Evangelho, Padilha, Telma França, Bouzas, Luiz Fernando, de Souza Fernandez, Teresa, Abdelhay, Eliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2012
Materias:
Human and Medical Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526078/
https://www.ncbi.nlm.nih.gov/pubmed/23271931
http://dx.doi.org/10.1590/S1415-47572012005000056
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author Otero, Luize
de Souza, Daiane Correa
de Cássia Tavares, Rita
Gomes, Bernadete Evangelho
Padilha, Telma França
Bouzas, Luiz Fernando
de Souza Fernandez, Teresa
Abdelhay, Eliana
author_facet Otero, Luize
de Souza, Daiane Correa
de Cássia Tavares, Rita
Gomes, Bernadete Evangelho
Padilha, Telma França
Bouzas, Luiz Fernando
de Souza Fernandez, Teresa
Abdelhay, Eliana
author_sort Otero, Luize
collection PubMed
description Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient’s bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.
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spelling pubmed-35260782012-12-27 Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature Otero, Luize de Souza, Daiane Correa de Cássia Tavares, Rita Gomes, Bernadete Evangelho Padilha, Telma França Bouzas, Luiz Fernando de Souza Fernandez, Teresa Abdelhay, Eliana Genet Mol Biol Human and Medical Genetics Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient’s bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells. Sociedade Brasileira de Genética 2012-12 2012-10-02 /pmc/articles/PMC3526078/ /pubmed/23271931 http://dx.doi.org/10.1590/S1415-47572012005000056 Text en Copyright © 2012, Sociedade Brasileira de Genética. License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Human and Medical Genetics
Otero, Luize
de Souza, Daiane Correa
de Cássia Tavares, Rita
Gomes, Bernadete Evangelho
Padilha, Telma França
Bouzas, Luiz Fernando
de Souza Fernandez, Teresa
Abdelhay, Eliana
Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature
title Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature
title_full Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature
title_fullStr Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature
title_full_unstemmed Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature
title_short Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature
title_sort monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature
topic Human and Medical Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526078/
https://www.ncbi.nlm.nih.gov/pubmed/23271931
http://dx.doi.org/10.1590/S1415-47572012005000056
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