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The promise of the anti-idiotype concept

A basic tenet of antibody-based immunity is their specificity to antigenic determinates from foreign pathogen products to abnormal cellular components such as in cancer. However, an antibody has the potential to bind to more than one determinate, be it an antigen or another antibody. These observati...

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Autores principales: Kieber-Emmons, Thomas, Monzavi-Karbassi, Bejatohlah, Pashov, Anastas, Saha, Somdutta, Murali, Ramachandran, Kohler, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526099/
https://www.ncbi.nlm.nih.gov/pubmed/23267437
http://dx.doi.org/10.3389/fonc.2012.00196
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author Kieber-Emmons, Thomas
Monzavi-Karbassi, Bejatohlah
Pashov, Anastas
Saha, Somdutta
Murali, Ramachandran
Kohler, Heinz
author_facet Kieber-Emmons, Thomas
Monzavi-Karbassi, Bejatohlah
Pashov, Anastas
Saha, Somdutta
Murali, Ramachandran
Kohler, Heinz
author_sort Kieber-Emmons, Thomas
collection PubMed
description A basic tenet of antibody-based immunity is their specificity to antigenic determinates from foreign pathogen products to abnormal cellular components such as in cancer. However, an antibody has the potential to bind to more than one determinate, be it an antigen or another antibody. These observations led to the idiotype network theory (INT) to explain immune regulation, which has wax and waned in enthusiasm over the years. A truer measure of the impact of the INT is in terms of the ideas that now form the mainstay of immunological research and whose roots are spawned from the promise of the anti-idiotype concept. Among the applications of the INT is understanding the structural implications of the antibody-mediated network that has the potential for innovation in terms of rational design of reagents with biological, chemical, and pharmaceutical applications that underlies concepts of reverse immunology which is highlighted herein.
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spelling pubmed-35260992012-12-24 The promise of the anti-idiotype concept Kieber-Emmons, Thomas Monzavi-Karbassi, Bejatohlah Pashov, Anastas Saha, Somdutta Murali, Ramachandran Kohler, Heinz Front Oncol Immunology A basic tenet of antibody-based immunity is their specificity to antigenic determinates from foreign pathogen products to abnormal cellular components such as in cancer. However, an antibody has the potential to bind to more than one determinate, be it an antigen or another antibody. These observations led to the idiotype network theory (INT) to explain immune regulation, which has wax and waned in enthusiasm over the years. A truer measure of the impact of the INT is in terms of the ideas that now form the mainstay of immunological research and whose roots are spawned from the promise of the anti-idiotype concept. Among the applications of the INT is understanding the structural implications of the antibody-mediated network that has the potential for innovation in terms of rational design of reagents with biological, chemical, and pharmaceutical applications that underlies concepts of reverse immunology which is highlighted herein. Frontiers Media S.A. 2012-12-19 /pmc/articles/PMC3526099/ /pubmed/23267437 http://dx.doi.org/10.3389/fonc.2012.00196 Text en Copyright © Kieber-Emmons, Monzavi-Karbassi, Pashov, Saha, Murali and Kohler. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Kieber-Emmons, Thomas
Monzavi-Karbassi, Bejatohlah
Pashov, Anastas
Saha, Somdutta
Murali, Ramachandran
Kohler, Heinz
The promise of the anti-idiotype concept
title The promise of the anti-idiotype concept
title_full The promise of the anti-idiotype concept
title_fullStr The promise of the anti-idiotype concept
title_full_unstemmed The promise of the anti-idiotype concept
title_short The promise of the anti-idiotype concept
title_sort promise of the anti-idiotype concept
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526099/
https://www.ncbi.nlm.nih.gov/pubmed/23267437
http://dx.doi.org/10.3389/fonc.2012.00196
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