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Association of particulate air pollution and secondhand smoke on endothelium-dependent brachial artery dilation in healthy children

BACKGROUND: This study aimed to determine the association of particulate matters with endothelial function, measured by flow mediated dilation (FMD) of brachial artery, in children with or without exposure to secondhand smoke. METHODS: This cross-sectional study was conducted from January to March 2...

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Autores principales: Hashemi, Mohammad, Afshani, Mohammad Reza, Mansourian, Marjan, Poursafa, Parinaz, Kelishadi, Roya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526122/
https://www.ncbi.nlm.nih.gov/pubmed/23267390
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author Hashemi, Mohammad
Afshani, Mohammad Reza
Mansourian, Marjan
Poursafa, Parinaz
Kelishadi, Roya
author_facet Hashemi, Mohammad
Afshani, Mohammad Reza
Mansourian, Marjan
Poursafa, Parinaz
Kelishadi, Roya
author_sort Hashemi, Mohammad
collection PubMed
description BACKGROUND: This study aimed to determine the association of particulate matters with endothelial function, measured by flow mediated dilation (FMD) of brachial artery, in children with or without exposure to secondhand smoke. METHODS: This cross-sectional study was conducted from January to March 2011 in Isfahan, which is the second large and air-polluted city in Iran. The areas of the city with lowest and highest air pollution were determined, and in each area, 25 prepubescent boys with or without exposure to daily tobacco smoke in home were selected, i.e. 100 children were studied in total. RESULTS: FMD was significantly smaller in those living in high-polluted area and those exposed to secondhand smoke. Multiple linear regression analysis, adjusted for age and body mass index, showed that both passive smoking status and living area in terms of particulate air pollution were effective determinants of the brachial artery diameter. The standardized coefficient of passive smoking status was –0.36 (SD = 0.09, P < 0.0001) showing negative association with percent increase in FMD. Likewise, the percent increase in brachial artery diameter was lower in passive smoker children. Similar relationship was documented for PM(10) concentration with a regression coefficient of –0.32 (SD = 0.04, P < 0.0001). Without considering passive smoking variable, PM(10) concentration has significant independent effect on FMD level. CONCLUSION: Our findings provide evidence on the association of environmental factors on endothelial dysfunction from early life. Studying such associations among healthy children may help identify the underlying mechanisms. The clinical implications of environmental factors on early stages of atherosclerosis should be confirmed in longitudinal studies.
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spelling pubmed-35261222012-12-24 Association of particulate air pollution and secondhand smoke on endothelium-dependent brachial artery dilation in healthy children Hashemi, Mohammad Afshani, Mohammad Reza Mansourian, Marjan Poursafa, Parinaz Kelishadi, Roya J Res Med Sci Original Article BACKGROUND: This study aimed to determine the association of particulate matters with endothelial function, measured by flow mediated dilation (FMD) of brachial artery, in children with or without exposure to secondhand smoke. METHODS: This cross-sectional study was conducted from January to March 2011 in Isfahan, which is the second large and air-polluted city in Iran. The areas of the city with lowest and highest air pollution were determined, and in each area, 25 prepubescent boys with or without exposure to daily tobacco smoke in home were selected, i.e. 100 children were studied in total. RESULTS: FMD was significantly smaller in those living in high-polluted area and those exposed to secondhand smoke. Multiple linear regression analysis, adjusted for age and body mass index, showed that both passive smoking status and living area in terms of particulate air pollution were effective determinants of the brachial artery diameter. The standardized coefficient of passive smoking status was –0.36 (SD = 0.09, P < 0.0001) showing negative association with percent increase in FMD. Likewise, the percent increase in brachial artery diameter was lower in passive smoker children. Similar relationship was documented for PM(10) concentration with a regression coefficient of –0.32 (SD = 0.04, P < 0.0001). Without considering passive smoking variable, PM(10) concentration has significant independent effect on FMD level. CONCLUSION: Our findings provide evidence on the association of environmental factors on endothelial dysfunction from early life. Studying such associations among healthy children may help identify the underlying mechanisms. The clinical implications of environmental factors on early stages of atherosclerosis should be confirmed in longitudinal studies. Medknow Publications & Media Pvt Ltd 2012-04 /pmc/articles/PMC3526122/ /pubmed/23267390 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hashemi, Mohammad
Afshani, Mohammad Reza
Mansourian, Marjan
Poursafa, Parinaz
Kelishadi, Roya
Association of particulate air pollution and secondhand smoke on endothelium-dependent brachial artery dilation in healthy children
title Association of particulate air pollution and secondhand smoke on endothelium-dependent brachial artery dilation in healthy children
title_full Association of particulate air pollution and secondhand smoke on endothelium-dependent brachial artery dilation in healthy children
title_fullStr Association of particulate air pollution and secondhand smoke on endothelium-dependent brachial artery dilation in healthy children
title_full_unstemmed Association of particulate air pollution and secondhand smoke on endothelium-dependent brachial artery dilation in healthy children
title_short Association of particulate air pollution and secondhand smoke on endothelium-dependent brachial artery dilation in healthy children
title_sort association of particulate air pollution and secondhand smoke on endothelium-dependent brachial artery dilation in healthy children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526122/
https://www.ncbi.nlm.nih.gov/pubmed/23267390
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