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Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited disorder, which is caused by a pathological expansion of a polyglutamine (polyQ) tract in the coding region of the ATXN2 gene. Like other ataxias, SCA2 most overtly affects Purkinje cells (PCs) in the cerebellum. Using a trans...

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Detalles Bibliográficos
Autores principales:	Hansen, Stephen T., Meera, Pratap, Otis, Thomas S., Pulst, Stefan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526159/ https://www.ncbi.nlm.nih.gov/pubmed/23087021 http://dx.doi.org/10.1093/hmg/dds427

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