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Personalized Genetic Risk Counseling to Motivate Diabetes Prevention: A randomized trial

OBJECTIVE: To examine whether diabetes genetic risk testing and counseling can improve diabetes prevention behaviors. RESEARCH DESIGN AND METHODS: We conducted a randomized trial of diabetes genetic risk counseling among overweight patients at increased phenotypic risk for type 2 diabetes. Participa...

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Autores principales: Grant, Richard W., O’Brien, Kelsey E., Waxler, Jessica L., Vassy, Jason L., Delahanty, Linda M., Bissett, Laurie G., Green, Robert C., Stember, Katherine G., Guiducci, Candace, Park, Elyse R., Florez, Jose C., Meigs, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526219/
https://www.ncbi.nlm.nih.gov/pubmed/22933432
http://dx.doi.org/10.2337/dc12-0884
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author Grant, Richard W.
O’Brien, Kelsey E.
Waxler, Jessica L.
Vassy, Jason L.
Delahanty, Linda M.
Bissett, Laurie G.
Green, Robert C.
Stember, Katherine G.
Guiducci, Candace
Park, Elyse R.
Florez, Jose C.
Meigs, James B.
author_facet Grant, Richard W.
O’Brien, Kelsey E.
Waxler, Jessica L.
Vassy, Jason L.
Delahanty, Linda M.
Bissett, Laurie G.
Green, Robert C.
Stember, Katherine G.
Guiducci, Candace
Park, Elyse R.
Florez, Jose C.
Meigs, James B.
author_sort Grant, Richard W.
collection PubMed
description OBJECTIVE: To examine whether diabetes genetic risk testing and counseling can improve diabetes prevention behaviors. RESEARCH DESIGN AND METHODS: We conducted a randomized trial of diabetes genetic risk counseling among overweight patients at increased phenotypic risk for type 2 diabetes. Participants were randomly allocated to genetic testing versus no testing. Genetic risk was calculated by summing 36 single nucleotide polymorphisms associated with type 2 diabetes. Participants in the top and bottom score quartiles received individual genetic counseling before being enrolled with untested control participants in a 12-week, validated, diabetes prevention program. Middle-risk quartile participants were not studied further. We examined the effect of this genetic counseling intervention on patient self-reported attitudes, program attendance, and weight loss, separately comparing higher-risk and lower-risk result recipients with control participants. RESULTS: The 108 participants enrolled in the diabetes prevention program included 42 participants at higher diabetes genetic risk, 32 at lower diabetes genetic risk, and 34 untested control subjects. Mean age was 57.9 ± 10.6 years, 61% were men, and average BMI was 34.8 kg/m(2), with no differences among randomization groups. Participants attended 6.8 ± 4.3 group sessions and lost 8.5 ± 10.1 pounds, with 33 of 108 (30.6%) losing ≥5% body weight. There were few statistically significant differences in self-reported motivation, program attendance, or mean weight loss when higher-risk recipients and lower-risk recipients were compared with control subjects (P > 0.05 for all but one comparison). CONCLUSIONS: Diabetes genetic risk counseling with currently available variants does not significantly alter self-reported motivation or prevention program adherence for overweight individuals at risk for diabetes.
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spelling pubmed-35262192014-01-01 Personalized Genetic Risk Counseling to Motivate Diabetes Prevention: A randomized trial Grant, Richard W. O’Brien, Kelsey E. Waxler, Jessica L. Vassy, Jason L. Delahanty, Linda M. Bissett, Laurie G. Green, Robert C. Stember, Katherine G. Guiducci, Candace Park, Elyse R. Florez, Jose C. Meigs, James B. Diabetes Care Original Research OBJECTIVE: To examine whether diabetes genetic risk testing and counseling can improve diabetes prevention behaviors. RESEARCH DESIGN AND METHODS: We conducted a randomized trial of diabetes genetic risk counseling among overweight patients at increased phenotypic risk for type 2 diabetes. Participants were randomly allocated to genetic testing versus no testing. Genetic risk was calculated by summing 36 single nucleotide polymorphisms associated with type 2 diabetes. Participants in the top and bottom score quartiles received individual genetic counseling before being enrolled with untested control participants in a 12-week, validated, diabetes prevention program. Middle-risk quartile participants were not studied further. We examined the effect of this genetic counseling intervention on patient self-reported attitudes, program attendance, and weight loss, separately comparing higher-risk and lower-risk result recipients with control participants. RESULTS: The 108 participants enrolled in the diabetes prevention program included 42 participants at higher diabetes genetic risk, 32 at lower diabetes genetic risk, and 34 untested control subjects. Mean age was 57.9 ± 10.6 years, 61% were men, and average BMI was 34.8 kg/m(2), with no differences among randomization groups. Participants attended 6.8 ± 4.3 group sessions and lost 8.5 ± 10.1 pounds, with 33 of 108 (30.6%) losing ≥5% body weight. There were few statistically significant differences in self-reported motivation, program attendance, or mean weight loss when higher-risk recipients and lower-risk recipients were compared with control subjects (P > 0.05 for all but one comparison). CONCLUSIONS: Diabetes genetic risk counseling with currently available variants does not significantly alter self-reported motivation or prevention program adherence for overweight individuals at risk for diabetes. American Diabetes Association 2013-01 2012-12-11 /pmc/articles/PMC3526219/ /pubmed/22933432 http://dx.doi.org/10.2337/dc12-0884 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Grant, Richard W.
O’Brien, Kelsey E.
Waxler, Jessica L.
Vassy, Jason L.
Delahanty, Linda M.
Bissett, Laurie G.
Green, Robert C.
Stember, Katherine G.
Guiducci, Candace
Park, Elyse R.
Florez, Jose C.
Meigs, James B.
Personalized Genetic Risk Counseling to Motivate Diabetes Prevention: A randomized trial
title Personalized Genetic Risk Counseling to Motivate Diabetes Prevention: A randomized trial
title_full Personalized Genetic Risk Counseling to Motivate Diabetes Prevention: A randomized trial
title_fullStr Personalized Genetic Risk Counseling to Motivate Diabetes Prevention: A randomized trial
title_full_unstemmed Personalized Genetic Risk Counseling to Motivate Diabetes Prevention: A randomized trial
title_short Personalized Genetic Risk Counseling to Motivate Diabetes Prevention: A randomized trial
title_sort personalized genetic risk counseling to motivate diabetes prevention: a randomized trial
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526219/
https://www.ncbi.nlm.nih.gov/pubmed/22933432
http://dx.doi.org/10.2337/dc12-0884
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