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β-Cell Mass and Turnover in Humans: Effects of obesity and aging

OBJECTIVE: We sought to establish β-cell mass, β-cell apoptosis, and β-cell replication in humans in response to obesity and advanced age. RESEARCH DESIGN AND METHODS: We examined human autopsy pancreas from 167 nondiabetic individuals 20–102 years of age. The effect of obesity on β-cell mass was ex...

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Detalles Bibliográficos
Autores principales:	Saisho, Yoshifumi, Butler, Alexandra E., Manesso, Erica, Elashoff, David, Rizza, Robert A., Butler, Peter C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526241/ https://www.ncbi.nlm.nih.gov/pubmed/22875233 http://dx.doi.org/10.2337/dc12-0421

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