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Sequence-specific cleavage of the RNA strand in DNA–RNA hybrids by the fusion of ribonuclease H with a zinc finger

Ribonucleases (RNases) are valuable tools applied in the analysis of RNA sequence, structure and function. Their substrate specificity is limited to recognition of single bases or distinct secondary structures in the substrate. Currently, there are no RNases available for purely sequence-dependent f...

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Detalles Bibliográficos
Autores principales:	Sulej, Agata A., Tuszynska, Irina, Skowronek, Krzysztof J., Nowotny, Marcin, Bujnicki, Janusz M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526281/ https://www.ncbi.nlm.nih.gov/pubmed/23042681 http://dx.doi.org/10.1093/nar/gks885

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