HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

The binding of integrase (IN) to lens epithelium-derived growth factor (LEDGF)/p75 in large part determines the efficiency and specificity of HIV-1 integration. However, a significant residual preference for integration into active genes persists in Psip1 (the gene that encodes for LEDGF/p75) knocko...

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Detalles Bibliográficos
Autores principales: Wang, Hao, Jurado, Kellie A., Wu, Xiaolin, Shun, Ming-Chieh, Li, Xiang, Ferris, Andrea L., Smith, Steven J., Patel, Pratiq A., Fuchs, James R., Cherepanov, Peter, Kvaratskhelia, Mamuka, Hughes, Stephen H., Engelman, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526291/
https://www.ncbi.nlm.nih.gov/pubmed/23042676
http://dx.doi.org/10.1093/nar/gks913

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