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Defining the functional footprint for recognition and repair of deaminated DNA

Spontaneous deamination of DNA is mutagenic, if it is not repaired by the base excision repair (BER) pathway. Crystallographic data suggest that each BER enzyme has a compact DNA binding site. However, these structures lack information about poorly ordered termini, and the energetic contributions of...

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Detalles Bibliográficos
Autores principales:	Baldwin, Michael R., O’Brien, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526306/ https://www.ncbi.nlm.nih.gov/pubmed/23074184 http://dx.doi.org/10.1093/nar/gks952

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