Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception

BACKGROUND: The Transient Receptor Potential (TRP) ion channel TRPA1 is a key player in pain pathways. Irritant chemicals activate ion channel TRPA1 via covalent modification of N-terminal cysteines. We and others have shown that 15-Deoxy-Δ12, 14-prostaglandin J(2) (15d-PGJ(2)) similarly activates T...

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Detalles Bibliográficos
Autores principales: Weng, Yingqi, Batista-Schepman, Patricia A, Barabas, Marie E, Harris, Eli Q, Dinsmore, Thomas B, Kossyreva, Elena A, Foshage, Audra M, Wang, Michelle H, Schwab, Matthew J, Wang, Victoria M, Stucky, Cheryl L, Story, Gina M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526547/
https://www.ncbi.nlm.nih.gov/pubmed/23013719
http://dx.doi.org/10.1186/1744-8069-8-75

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