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Notch1 Is Not Required for Acinar-to-Ductal Metaplasia in a Model of Kras-Induced Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma is believed to arise from precursor lesions termed pancreatic intraepithelial neoplasia (PanIN). Mouse models have demonstrated that targeted expression of activated K-ras to mature acinar cells in the pancreas induces the spontaneous development of PanIN lesions; im...

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Detalles Bibliográficos
Autores principales:	Avila, Jacqueline L., Troutman, Scott, Durham, Amy, Kissil, Joseph L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526595/ https://www.ncbi.nlm.nih.gov/pubmed/23284900 http://dx.doi.org/10.1371/journal.pone.0052133

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