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Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme
BACKGROUND: Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of phys...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526776/ https://www.ncbi.nlm.nih.gov/pubmed/23072920 http://dx.doi.org/10.1016/j.bone.2012.10.004 |
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author | Alfred, Tamuno Ben-Shlomo, Yoav Cooper, Rachel Hardy, Rebecca Cooper, Cyrus Deary, Ian J. Gunnell, David Harris, Sarah E. Kumari, Meena Martin, Richard M. Sayer, Avan Aihie Starr, John M. Kuh, Diana Day, Ian N.M. |
author_facet | Alfred, Tamuno Ben-Shlomo, Yoav Cooper, Rachel Hardy, Rebecca Cooper, Cyrus Deary, Ian J. Gunnell, David Harris, Sarah E. Kumari, Meena Martin, Richard M. Sayer, Avan Aihie Starr, John M. Kuh, Diana Day, Ian N.M. |
author_sort | Alfred, Tamuno |
collection | PubMed |
description | BACKGROUND: Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability. METHODS: As part of the Healthy Ageing across the Life Course (HALCyon) programme, men and women aged between 52 and 90 + years from six UK cohorts were genotyped for a polymorphism associated with serum calcium (rs1801725, CASR), two polymorphisms associated with bone mineral density (BMD) (rs2941740, ESR1 and rs9594759, RANKL) and one associated with osteoarthritis risk rs3815148 (COG5). Meta-analysis was used to pool within-study effects of the associations between each of the polymorphisms and measures of physical capability: grip strength, timed walk or get up and go, chair rises and standing balance. RESULTS: Few important associations were observed among the several tests. We found that carriers of the serum calcium-raising allele had poorer grip strength compared with non-carriers (pooled p = 0.05, n = 11,239) after adjusting for age and sex. Inconsistent results were observed for the two variants associated with BMD and we found no evidence for an association between rs3815148 (COG5) and any of the physical capability measures. CONCLUSION: Our findings suggest elevated serum calcium levels may lead to lower grip strength, though this requires further replication. Our results do not provide evidence for a substantial influence of these variants in ESR1, RANKL and COG5 on physical capability in older adults. |
format | Online Article Text |
id | pubmed-3526776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35267762013-01-01 Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme Alfred, Tamuno Ben-Shlomo, Yoav Cooper, Rachel Hardy, Rebecca Cooper, Cyrus Deary, Ian J. Gunnell, David Harris, Sarah E. Kumari, Meena Martin, Richard M. Sayer, Avan Aihie Starr, John M. Kuh, Diana Day, Ian N.M. Bone Original Full Length Article BACKGROUND: Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability. METHODS: As part of the Healthy Ageing across the Life Course (HALCyon) programme, men and women aged between 52 and 90 + years from six UK cohorts were genotyped for a polymorphism associated with serum calcium (rs1801725, CASR), two polymorphisms associated with bone mineral density (BMD) (rs2941740, ESR1 and rs9594759, RANKL) and one associated with osteoarthritis risk rs3815148 (COG5). Meta-analysis was used to pool within-study effects of the associations between each of the polymorphisms and measures of physical capability: grip strength, timed walk or get up and go, chair rises and standing balance. RESULTS: Few important associations were observed among the several tests. We found that carriers of the serum calcium-raising allele had poorer grip strength compared with non-carriers (pooled p = 0.05, n = 11,239) after adjusting for age and sex. Inconsistent results were observed for the two variants associated with BMD and we found no evidence for an association between rs3815148 (COG5) and any of the physical capability measures. CONCLUSION: Our findings suggest elevated serum calcium levels may lead to lower grip strength, though this requires further replication. Our results do not provide evidence for a substantial influence of these variants in ESR1, RANKL and COG5 on physical capability in older adults. Elsevier Science 2013-01 /pmc/articles/PMC3526776/ /pubmed/23072920 http://dx.doi.org/10.1016/j.bone.2012.10.004 Text en © 2013 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
spellingShingle | Original Full Length Article Alfred, Tamuno Ben-Shlomo, Yoav Cooper, Rachel Hardy, Rebecca Cooper, Cyrus Deary, Ian J. Gunnell, David Harris, Sarah E. Kumari, Meena Martin, Richard M. Sayer, Avan Aihie Starr, John M. Kuh, Diana Day, Ian N.M. Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme |
title | Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme |
title_full | Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme |
title_fullStr | Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme |
title_full_unstemmed | Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme |
title_short | Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme |
title_sort | genetic markers of bone and joint health and physical capability in older adults: the halcyon programme |
topic | Original Full Length Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526776/ https://www.ncbi.nlm.nih.gov/pubmed/23072920 http://dx.doi.org/10.1016/j.bone.2012.10.004 |
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