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Positive predictive value of the diagnosis coding for vitamin B12 deficiency anemia in the Danish National Patient Register

PURPOSE: The aim of this validation study was to assess the positive predictive value (PPV) of the International Classification of Diseases, 10th revision (ICD-10) diagnosis of vitamin B12 (cobalamin [Cbl]) deficiency anemia in the Danish National Patient Register (DNPR). PATIENTS AND METHODS: We id...

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Autores principales: Ben Ghezala, Inès, Arendt, Johan Frederik Berg, Erichsen, Rune, Zalfani, Jihen, Gammelager, Henrik, Frøslev, Trine, Olsen, Morten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526860/
https://www.ncbi.nlm.nih.gov/pubmed/23271924
http://dx.doi.org/10.2147/CLEP.S38229
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author Ben Ghezala, Inès
Arendt, Johan Frederik Berg
Erichsen, Rune
Zalfani, Jihen
Gammelager, Henrik
Frøslev, Trine
Olsen, Morten
author_facet Ben Ghezala, Inès
Arendt, Johan Frederik Berg
Erichsen, Rune
Zalfani, Jihen
Gammelager, Henrik
Frøslev, Trine
Olsen, Morten
author_sort Ben Ghezala, Inès
collection PubMed
description PURPOSE: The aim of this validation study was to assess the positive predictive value (PPV) of the International Classification of Diseases, 10th revision (ICD-10) diagnosis of vitamin B12 (cobalamin [Cbl]) deficiency anemia in the Danish National Patient Register (DNPR). PATIENTS AND METHODS: We identified all patients above 18 years of age recorded in the DNPR with a diagnosis of Cbl deficiency anemia (ICD-10 code: D51) admitted to two Danish university hospitals and one Danish regional hospital from 2000 through 2009. We assessed the PPV using biochemical parameters on Cbl deficiency with or without anemia as reference standards. These data were obtained from the Laboratory Information Systems Database. Data on prescriptions with Cbl supplementation drugs were obtained from the Aarhus University Prescription Database. RESULTS: We identified 1089 patients coded with a Cbl deficiency anemia diagnosis in the DNPR. The PPV was 31.5% (95% confidence interval [CI]: 28.8%–34.3%) and 36.8% (95% CI: 34.0%–39.7%) depending on definitions of Cbl deficiency with anemia. When using Cbl deficiency without anemia as a reference standard, the PPV was 51.3% (95% CI: 48.4%–54.3%). The PPV for Cbl supplemented patients was 22.2% (95% CI: 18.0%–26.9%) and for non-Cbl supplemented patients 63.9% (95% CI: 60.5%–67.3%). CONCLUSION: The PPVs of the ICD-10 diagnosis coding for Cbl deficiency anemia were generally low in the DNPR. Therefore, this register should be used with caution to study patients with Cbl deficiency anemia.
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spelling pubmed-35268602012-12-27 Positive predictive value of the diagnosis coding for vitamin B12 deficiency anemia in the Danish National Patient Register Ben Ghezala, Inès Arendt, Johan Frederik Berg Erichsen, Rune Zalfani, Jihen Gammelager, Henrik Frøslev, Trine Olsen, Morten Clin Epidemiol Short Report PURPOSE: The aim of this validation study was to assess the positive predictive value (PPV) of the International Classification of Diseases, 10th revision (ICD-10) diagnosis of vitamin B12 (cobalamin [Cbl]) deficiency anemia in the Danish National Patient Register (DNPR). PATIENTS AND METHODS: We identified all patients above 18 years of age recorded in the DNPR with a diagnosis of Cbl deficiency anemia (ICD-10 code: D51) admitted to two Danish university hospitals and one Danish regional hospital from 2000 through 2009. We assessed the PPV using biochemical parameters on Cbl deficiency with or without anemia as reference standards. These data were obtained from the Laboratory Information Systems Database. Data on prescriptions with Cbl supplementation drugs were obtained from the Aarhus University Prescription Database. RESULTS: We identified 1089 patients coded with a Cbl deficiency anemia diagnosis in the DNPR. The PPV was 31.5% (95% confidence interval [CI]: 28.8%–34.3%) and 36.8% (95% CI: 34.0%–39.7%) depending on definitions of Cbl deficiency with anemia. When using Cbl deficiency without anemia as a reference standard, the PPV was 51.3% (95% CI: 48.4%–54.3%). The PPV for Cbl supplemented patients was 22.2% (95% CI: 18.0%–26.9%) and for non-Cbl supplemented patients 63.9% (95% CI: 60.5%–67.3%). CONCLUSION: The PPVs of the ICD-10 diagnosis coding for Cbl deficiency anemia were generally low in the DNPR. Therefore, this register should be used with caution to study patients with Cbl deficiency anemia. Dove Medical Press 2012-12-04 /pmc/articles/PMC3526860/ /pubmed/23271924 http://dx.doi.org/10.2147/CLEP.S38229 Text en © 2012 Ben Ghezala et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Short Report
Ben Ghezala, Inès
Arendt, Johan Frederik Berg
Erichsen, Rune
Zalfani, Jihen
Gammelager, Henrik
Frøslev, Trine
Olsen, Morten
Positive predictive value of the diagnosis coding for vitamin B12 deficiency anemia in the Danish National Patient Register
title Positive predictive value of the diagnosis coding for vitamin B12 deficiency anemia in the Danish National Patient Register
title_full Positive predictive value of the diagnosis coding for vitamin B12 deficiency anemia in the Danish National Patient Register
title_fullStr Positive predictive value of the diagnosis coding for vitamin B12 deficiency anemia in the Danish National Patient Register
title_full_unstemmed Positive predictive value of the diagnosis coding for vitamin B12 deficiency anemia in the Danish National Patient Register
title_short Positive predictive value of the diagnosis coding for vitamin B12 deficiency anemia in the Danish National Patient Register
title_sort positive predictive value of the diagnosis coding for vitamin b12 deficiency anemia in the danish national patient register
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526860/
https://www.ncbi.nlm.nih.gov/pubmed/23271924
http://dx.doi.org/10.2147/CLEP.S38229
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