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Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart

Klotho is a membrane protein predominantly produced in the kidney that exerts some anti-ageing effects. Ageing is associated with an increased risk of heart failure; whether Klotho is cardioprotective is unknown. Here we show that Klotho-deficient mice have no baseline cardiac abnormalities but deve...

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Detalles Bibliográficos
Autores principales:	Xie, Jian, Cha, Seung-Kuy, An, Sung-Wan, Kuro-o, Makoto, Birnbaumer, Lutz, Huang, Chou-Long
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526952/ https://www.ncbi.nlm.nih.gov/pubmed/23212367 http://dx.doi.org/10.1038/ncomms2240

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