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Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells

BACKGROUND: Arachidonic acid metabolite, generated by cyclooxygenase (COX), is implicated in the colorectal cancer (CRC) pathogenesis. Inhibiting COX may therefore have anti-carcinogenic effects. Results from use of non-steroidal anti-inflammatory drugs inhibiting only COX have been conflicting. It...

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Detalles Bibliográficos
Autores principales:	Ganesh, Radhakrishnan, Marks, Daniel JB, Sales, Kevin, Winslet, Marc C, Seifalian, Alexander M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527267/ https://www.ncbi.nlm.nih.gov/pubmed/23013454 http://dx.doi.org/10.1186/1477-7819-10-200

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