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Mi2β Is Required for γ-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in β-YAC Transgenic Mice

Activation of γ-globin gene expression in adults is known to be therapeutic for sickle cell disease. Thus, it follows that the converse, alleviation of repression, would be equally effective, since the net result would be the same: an increase in fetal hemoglobin. A GATA-1-FOG-1-Mi2 repressor comple...

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Detalles Bibliográficos
Autores principales:	Costa, Flávia C., Fedosyuk, Halyna, Chazelle, Allen M., Neades, Renee Y., Peterson, Kenneth R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527334/ https://www.ncbi.nlm.nih.gov/pubmed/23284307 http://dx.doi.org/10.1371/journal.pgen.1003155

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