Transport Mechanisms and Their Pathology-Induced Regulation Govern Tyrosine Kinase Inhibitor Delivery in Rheumatoid Arthritis

BACKGROUND: Tyrosine kinase inhibitors (TKIs) are effective in treating malignant disorders and were lately suggested to have an impact on non-malignant diseases. However, in some inflammatory conditions like rheumatoid arthritis (RA) the in vivo effect seemed to be moderate. As most TKIs are taken...

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Detalles Bibliográficos
Autores principales: Schmidt-Lauber, Christian, Harrach, Saliha, Pap, Thomas, Fischer, Meike, Victor, Marion, Heitzmann, Marianne, Hansen, Uwe, Fobker, Manfred, Brand, Stefan-Martin, Sindic, Aleksandra, Pavenstädt, Hermann, Edemir, Bayram, Schlatter, Eberhard, Bertrand, Jessica, Ciarimboli, Giuliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527388/
https://www.ncbi.nlm.nih.gov/pubmed/23284953
http://dx.doi.org/10.1371/journal.pone.0052247

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