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The Sodium-Potassium Pump Controls the Intrinsic Firing of the Cerebellar Purkinje Neuron

In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence. The bimodal pattern consists of tonic spiking and quiescence. It is unclear how these firing patterns are...

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Detalles Bibliográficos
Autores principales: Forrest, Michael D., Wall, Mark J., Press, Daniel A., Feng, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527461/
https://www.ncbi.nlm.nih.gov/pubmed/23284664
http://dx.doi.org/10.1371/journal.pone.0051169
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author Forrest, Michael D.
Wall, Mark J.
Press, Daniel A.
Feng, Jianfeng
author_facet Forrest, Michael D.
Wall, Mark J.
Press, Daniel A.
Feng, Jianfeng
author_sort Forrest, Michael D.
collection PubMed
description In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence. The bimodal pattern consists of tonic spiking and quiescence. It is unclear how these firing patterns are generated and what determines which firing pattern is selected. We have constructed a realistic biophysical Purkinje cell model that can replicate these patterns. In this model, Na(+)/K(+) pump activity sets the Purkinje cell's operating mode. From rat cerebellar slices we present Purkinje whole cell recordings in the presence of ouabain, which irreversibly blocks the Na(+)/K(+) pump. The model can replicate these recordings. We propose that Na(+)/K(+) pump activity controls the intrinsic firing mode of cerbellar Purkinje cells.
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spelling pubmed-35274612013-01-02 The Sodium-Potassium Pump Controls the Intrinsic Firing of the Cerebellar Purkinje Neuron Forrest, Michael D. Wall, Mark J. Press, Daniel A. Feng, Jianfeng PLoS One Research Article In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence. The bimodal pattern consists of tonic spiking and quiescence. It is unclear how these firing patterns are generated and what determines which firing pattern is selected. We have constructed a realistic biophysical Purkinje cell model that can replicate these patterns. In this model, Na(+)/K(+) pump activity sets the Purkinje cell's operating mode. From rat cerebellar slices we present Purkinje whole cell recordings in the presence of ouabain, which irreversibly blocks the Na(+)/K(+) pump. The model can replicate these recordings. We propose that Na(+)/K(+) pump activity controls the intrinsic firing mode of cerbellar Purkinje cells. Public Library of Science 2012-12-20 /pmc/articles/PMC3527461/ /pubmed/23284664 http://dx.doi.org/10.1371/journal.pone.0051169 Text en © 2012 Forrest et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Forrest, Michael D.
Wall, Mark J.
Press, Daniel A.
Feng, Jianfeng
The Sodium-Potassium Pump Controls the Intrinsic Firing of the Cerebellar Purkinje Neuron
title The Sodium-Potassium Pump Controls the Intrinsic Firing of the Cerebellar Purkinje Neuron
title_full The Sodium-Potassium Pump Controls the Intrinsic Firing of the Cerebellar Purkinje Neuron
title_fullStr The Sodium-Potassium Pump Controls the Intrinsic Firing of the Cerebellar Purkinje Neuron
title_full_unstemmed The Sodium-Potassium Pump Controls the Intrinsic Firing of the Cerebellar Purkinje Neuron
title_short The Sodium-Potassium Pump Controls the Intrinsic Firing of the Cerebellar Purkinje Neuron
title_sort sodium-potassium pump controls the intrinsic firing of the cerebellar purkinje neuron
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527461/
https://www.ncbi.nlm.nih.gov/pubmed/23284664
http://dx.doi.org/10.1371/journal.pone.0051169
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