The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development

THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological...

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Detalles Bibliográficos
Autores principales: Castellano-Pozo, Maikel, García-Muse, Tatiana, Aguilera, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527488/
https://www.ncbi.nlm.nih.gov/pubmed/23285047
http://dx.doi.org/10.1371/journal.pone.0052447
Descripción
Sumario:THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using Caenorhabditis elegans as a model system we show that the THO complex is essential for mitotic genome integrity and the developmentally regulated mitotic cell cycles occurring during late postembryonic stages.

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