The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development

THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological...

Descripción completa

Detalles Bibliográficos
Autores principales: Castellano-Pozo, Maikel, García-Muse, Tatiana, Aguilera, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527488/
https://www.ncbi.nlm.nih.gov/pubmed/23285047
http://dx.doi.org/10.1371/journal.pone.0052447
_version_ 1782253734263259136
author Castellano-Pozo, Maikel
García-Muse, Tatiana
Aguilera, Andrés
author_facet Castellano-Pozo, Maikel
García-Muse, Tatiana
Aguilera, Andrés
author_sort Castellano-Pozo, Maikel
collection PubMed
description THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using Caenorhabditis elegans as a model system we show that the THO complex is essential for mitotic genome integrity and the developmentally regulated mitotic cell cycles occurring during late postembryonic stages.
format Online
Article
Text
id pubmed-3527488
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-35274882013-01-02 The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development Castellano-Pozo, Maikel García-Muse, Tatiana Aguilera, Andrés PLoS One Research Article THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using Caenorhabditis elegans as a model system we show that the THO complex is essential for mitotic genome integrity and the developmentally regulated mitotic cell cycles occurring during late postembryonic stages. Public Library of Science 2012-12-20 /pmc/articles/PMC3527488/ /pubmed/23285047 http://dx.doi.org/10.1371/journal.pone.0052447 Text en © 2012 Castellano-Pozo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Castellano-Pozo, Maikel
García-Muse, Tatiana
Aguilera, Andrés
The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development
title The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development
title_full The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development
title_fullStr The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development
title_full_unstemmed The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development
title_short The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development
title_sort caenorhabditis elegans tho complex is required for the mitotic cell cycle and development
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527488/
https://www.ncbi.nlm.nih.gov/pubmed/23285047
http://dx.doi.org/10.1371/journal.pone.0052447
work_keys_str_mv AT castellanopozomaikel thecaenorhabditiselegansthocomplexisrequiredforthemitoticcellcycleanddevelopment
AT garciamusetatiana thecaenorhabditiselegansthocomplexisrequiredforthemitoticcellcycleanddevelopment
AT aguileraandres thecaenorhabditiselegansthocomplexisrequiredforthemitoticcellcycleanddevelopment
AT castellanopozomaikel caenorhabditiselegansthocomplexisrequiredforthemitoticcellcycleanddevelopment
AT garciamusetatiana caenorhabditiselegansthocomplexisrequiredforthemitoticcellcycleanddevelopment
AT aguileraandres caenorhabditiselegansthocomplexisrequiredforthemitoticcellcycleanddevelopment

Ejemplares similares