Context- and Cell-Dependent Effects of Delta-Like 4 Targeting in the Bone Marrow Microenvironment

Delta-like 4 (Dll4) is a ligand of the Notch pathway family which has been widely studied in the context of tumor angiogenesis, its blockade shown to result in non-productive angiogenesis and halted tumor growth. As Dll4 inhibitors enter the clinic, there is an emerging need to understand their side...

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Detalles Bibliográficos
Autores principales: Remédio, Leonor, Carvalho, Tânia, Caiado, Francisco, Bastos-Carvalho, Ana, Martins, Diana, Duarte, António, Yagita, Hideo, Dias, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527506/
https://www.ncbi.nlm.nih.gov/pubmed/23285048
http://dx.doi.org/10.1371/journal.pone.0052450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527506/
https://www.ncbi.nlm.nih.gov/pubmed/23285048
http://dx.doi.org/10.1371/journal.pone.0052450

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