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Context- and Cell-Dependent Effects of Delta-Like 4 Targeting in the Bone Marrow Microenvironment
Delta-like 4 (Dll4) is a ligand of the Notch pathway family which has been widely studied in the context of tumor angiogenesis, its blockade shown to result in non-productive angiogenesis and halted tumor growth. As Dll4 inhibitors enter the clinic, there is an emerging need to understand their side...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527506/ https://www.ncbi.nlm.nih.gov/pubmed/23285048 http://dx.doi.org/10.1371/journal.pone.0052450 |