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Methylene Blue Reduced Abnormal Tau Accumulation in P301L Tau Transgenic Mice
In neurodegenerative disorders, abnormally hyperphosphorylated and aggregated tau accumulates intracellularly, a mechanism which is thought to induce neuronal cell death. Methylene blue, a type of phenothiazine, has been reported to inhibit tau aggregation in vitro. However, the effect of methylene...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527507/ https://www.ncbi.nlm.nih.gov/pubmed/23285020 http://dx.doi.org/10.1371/journal.pone.0052389 |