Up-regulated miR155 Reverses the Epithelial-mesenchymal Transition Induced by EGF and Increases Chemo-sensitivity to Cisplatin in Human Caski Cervical Cancer Cells

The epithelial-mesenchymal transition (EMT) induced by EGF promotes cervical cancer progression; however, the mechanisms underlying the EGF-induced EMT remain unclear. In this study, we reported that miR155 overexpression suppressed EGF-induced EMT, decreased migration/invasion capacities, inhibited...

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Autores principales: Lei, Cui, Wang, Yanlin, Huang, Yurong, Yu, Han, Huang, Yiling, Wu, Liting, Huang, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527539/
https://www.ncbi.nlm.nih.gov/pubmed/23284982
http://dx.doi.org/10.1371/journal.pone.0052310
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author Lei, Cui
Wang, Yanlin
Huang, Yurong
Yu, Han
Huang, Yiling
Wu, Liting
Huang, Liming
author_facet Lei, Cui
Wang, Yanlin
Huang, Yurong
Yu, Han
Huang, Yiling
Wu, Liting
Huang, Liming
author_sort Lei, Cui
collection PubMed
description The epithelial-mesenchymal transition (EMT) induced by EGF promotes cervical cancer progression; however, the mechanisms underlying the EGF-induced EMT remain unclear. In this study, we reported that miR155 overexpression suppressed EGF-induced EMT, decreased migration/invasion capacities, inhibited cell proliferation and increased the chemo-sensitivity to DDP in human Caski cervical cancer cells. Further, the overexpression of miR155 increased TP53 expression but reduced SMAD2, and CCND1 expression levels. These data suggest that miR155 negatively regulates EGF-induced EMT. We conclude that miR155 does not act as an oncogene but as a tumour suppressor in Caski cells.
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spelling pubmed-35275392013-01-02 Up-regulated miR155 Reverses the Epithelial-mesenchymal Transition Induced by EGF and Increases Chemo-sensitivity to Cisplatin in Human Caski Cervical Cancer Cells Lei, Cui Wang, Yanlin Huang, Yurong Yu, Han Huang, Yiling Wu, Liting Huang, Liming PLoS One Research Article The epithelial-mesenchymal transition (EMT) induced by EGF promotes cervical cancer progression; however, the mechanisms underlying the EGF-induced EMT remain unclear. In this study, we reported that miR155 overexpression suppressed EGF-induced EMT, decreased migration/invasion capacities, inhibited cell proliferation and increased the chemo-sensitivity to DDP in human Caski cervical cancer cells. Further, the overexpression of miR155 increased TP53 expression but reduced SMAD2, and CCND1 expression levels. These data suggest that miR155 negatively regulates EGF-induced EMT. We conclude that miR155 does not act as an oncogene but as a tumour suppressor in Caski cells. Public Library of Science 2012-12-20 /pmc/articles/PMC3527539/ /pubmed/23284982 http://dx.doi.org/10.1371/journal.pone.0052310 Text en © 2012 Lei et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lei, Cui
Wang, Yanlin
Huang, Yurong
Yu, Han
Huang, Yiling
Wu, Liting
Huang, Liming
Up-regulated miR155 Reverses the Epithelial-mesenchymal Transition Induced by EGF and Increases Chemo-sensitivity to Cisplatin in Human Caski Cervical Cancer Cells
title Up-regulated miR155 Reverses the Epithelial-mesenchymal Transition Induced by EGF and Increases Chemo-sensitivity to Cisplatin in Human Caski Cervical Cancer Cells
title_full Up-regulated miR155 Reverses the Epithelial-mesenchymal Transition Induced by EGF and Increases Chemo-sensitivity to Cisplatin in Human Caski Cervical Cancer Cells
title_fullStr Up-regulated miR155 Reverses the Epithelial-mesenchymal Transition Induced by EGF and Increases Chemo-sensitivity to Cisplatin in Human Caski Cervical Cancer Cells
title_full_unstemmed Up-regulated miR155 Reverses the Epithelial-mesenchymal Transition Induced by EGF and Increases Chemo-sensitivity to Cisplatin in Human Caski Cervical Cancer Cells
title_short Up-regulated miR155 Reverses the Epithelial-mesenchymal Transition Induced by EGF and Increases Chemo-sensitivity to Cisplatin in Human Caski Cervical Cancer Cells
title_sort up-regulated mir155 reverses the epithelial-mesenchymal transition induced by egf and increases chemo-sensitivity to cisplatin in human caski cervical cancer cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527539/
https://www.ncbi.nlm.nih.gov/pubmed/23284982
http://dx.doi.org/10.1371/journal.pone.0052310
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