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fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections

Recording of slow spontaneous fluctuations at rest using functional magnetic resonance imaging (fMRI) allows distinct long-range cortical networks to be identified. The neuronal basis of connectivity as assessed by resting-state fMRI still needs to be fully clarified, considering that these signals...

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Detalles Bibliográficos
Autores principales: Koch, Giacomo, Bozzali, Marco, Bonnì, Sonia, Giacobbe, Viola, Caltagirone, Carlo, Cercignani, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527573/
https://www.ncbi.nlm.nih.gov/pubmed/23285136
http://dx.doi.org/10.1371/journal.pone.0052660
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author Koch, Giacomo
Bozzali, Marco
Bonnì, Sonia
Giacobbe, Viola
Caltagirone, Carlo
Cercignani, Mara
author_facet Koch, Giacomo
Bozzali, Marco
Bonnì, Sonia
Giacobbe, Viola
Caltagirone, Carlo
Cercignani, Mara
author_sort Koch, Giacomo
collection PubMed
description Recording of slow spontaneous fluctuations at rest using functional magnetic resonance imaging (fMRI) allows distinct long-range cortical networks to be identified. The neuronal basis of connectivity as assessed by resting-state fMRI still needs to be fully clarified, considering that these signals are an indirect measure of neuronal activity, reflecting slow local variations in de-oxyhaemoglobin concentration. Here, we combined fMRI with multifocal transcranial magnetic stimulation (TMS), a technique that allows the investigation of the causal neurophysiological interactions occurring in specific cortico-cortical connections. We investigated whether the physiological properties of parieto-frontal circuits mapped with short-latency multifocal TMS at rest may have some relationship with the resting-state fMRI measures of specific resting-state functional networks (RSNs). Results showed that the activity of fast cortico-cortical physiological interactions occurring in the millisecond range correlated selectively with the coupling of fMRI slow oscillations within the same cortical areas that form part of the dorsal attention network, i.e., the attention system believed to be involved in reorientation of attention. We conclude that resting-state fMRI ongoing slow fluctuations likely reflect the interaction of underlying physiological cortico-cortical connections.
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spelling pubmed-35275732013-01-02 fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections Koch, Giacomo Bozzali, Marco Bonnì, Sonia Giacobbe, Viola Caltagirone, Carlo Cercignani, Mara PLoS One Research Article Recording of slow spontaneous fluctuations at rest using functional magnetic resonance imaging (fMRI) allows distinct long-range cortical networks to be identified. The neuronal basis of connectivity as assessed by resting-state fMRI still needs to be fully clarified, considering that these signals are an indirect measure of neuronal activity, reflecting slow local variations in de-oxyhaemoglobin concentration. Here, we combined fMRI with multifocal transcranial magnetic stimulation (TMS), a technique that allows the investigation of the causal neurophysiological interactions occurring in specific cortico-cortical connections. We investigated whether the physiological properties of parieto-frontal circuits mapped with short-latency multifocal TMS at rest may have some relationship with the resting-state fMRI measures of specific resting-state functional networks (RSNs). Results showed that the activity of fast cortico-cortical physiological interactions occurring in the millisecond range correlated selectively with the coupling of fMRI slow oscillations within the same cortical areas that form part of the dorsal attention network, i.e., the attention system believed to be involved in reorientation of attention. We conclude that resting-state fMRI ongoing slow fluctuations likely reflect the interaction of underlying physiological cortico-cortical connections. Public Library of Science 2012-12-20 /pmc/articles/PMC3527573/ /pubmed/23285136 http://dx.doi.org/10.1371/journal.pone.0052660 Text en © 2012 Koch et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Koch, Giacomo
Bozzali, Marco
Bonnì, Sonia
Giacobbe, Viola
Caltagirone, Carlo
Cercignani, Mara
fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections
title fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections
title_full fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections
title_fullStr fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections
title_full_unstemmed fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections
title_short fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections
title_sort fmri resting slow fluctuations correlate with the activity of fast cortico-cortical physiological connections
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527573/
https://www.ncbi.nlm.nih.gov/pubmed/23285136
http://dx.doi.org/10.1371/journal.pone.0052660
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