Cargando…
fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections
Recording of slow spontaneous fluctuations at rest using functional magnetic resonance imaging (fMRI) allows distinct long-range cortical networks to be identified. The neuronal basis of connectivity as assessed by resting-state fMRI still needs to be fully clarified, considering that these signals...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527573/ https://www.ncbi.nlm.nih.gov/pubmed/23285136 http://dx.doi.org/10.1371/journal.pone.0052660 |
_version_ | 1782253753429131264 |
---|---|
author | Koch, Giacomo Bozzali, Marco Bonnì, Sonia Giacobbe, Viola Caltagirone, Carlo Cercignani, Mara |
author_facet | Koch, Giacomo Bozzali, Marco Bonnì, Sonia Giacobbe, Viola Caltagirone, Carlo Cercignani, Mara |
author_sort | Koch, Giacomo |
collection | PubMed |
description | Recording of slow spontaneous fluctuations at rest using functional magnetic resonance imaging (fMRI) allows distinct long-range cortical networks to be identified. The neuronal basis of connectivity as assessed by resting-state fMRI still needs to be fully clarified, considering that these signals are an indirect measure of neuronal activity, reflecting slow local variations in de-oxyhaemoglobin concentration. Here, we combined fMRI with multifocal transcranial magnetic stimulation (TMS), a technique that allows the investigation of the causal neurophysiological interactions occurring in specific cortico-cortical connections. We investigated whether the physiological properties of parieto-frontal circuits mapped with short-latency multifocal TMS at rest may have some relationship with the resting-state fMRI measures of specific resting-state functional networks (RSNs). Results showed that the activity of fast cortico-cortical physiological interactions occurring in the millisecond range correlated selectively with the coupling of fMRI slow oscillations within the same cortical areas that form part of the dorsal attention network, i.e., the attention system believed to be involved in reorientation of attention. We conclude that resting-state fMRI ongoing slow fluctuations likely reflect the interaction of underlying physiological cortico-cortical connections. |
format | Online Article Text |
id | pubmed-3527573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35275732013-01-02 fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections Koch, Giacomo Bozzali, Marco Bonnì, Sonia Giacobbe, Viola Caltagirone, Carlo Cercignani, Mara PLoS One Research Article Recording of slow spontaneous fluctuations at rest using functional magnetic resonance imaging (fMRI) allows distinct long-range cortical networks to be identified. The neuronal basis of connectivity as assessed by resting-state fMRI still needs to be fully clarified, considering that these signals are an indirect measure of neuronal activity, reflecting slow local variations in de-oxyhaemoglobin concentration. Here, we combined fMRI with multifocal transcranial magnetic stimulation (TMS), a technique that allows the investigation of the causal neurophysiological interactions occurring in specific cortico-cortical connections. We investigated whether the physiological properties of parieto-frontal circuits mapped with short-latency multifocal TMS at rest may have some relationship with the resting-state fMRI measures of specific resting-state functional networks (RSNs). Results showed that the activity of fast cortico-cortical physiological interactions occurring in the millisecond range correlated selectively with the coupling of fMRI slow oscillations within the same cortical areas that form part of the dorsal attention network, i.e., the attention system believed to be involved in reorientation of attention. We conclude that resting-state fMRI ongoing slow fluctuations likely reflect the interaction of underlying physiological cortico-cortical connections. Public Library of Science 2012-12-20 /pmc/articles/PMC3527573/ /pubmed/23285136 http://dx.doi.org/10.1371/journal.pone.0052660 Text en © 2012 Koch et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Koch, Giacomo Bozzali, Marco Bonnì, Sonia Giacobbe, Viola Caltagirone, Carlo Cercignani, Mara fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections |
title | fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections |
title_full | fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections |
title_fullStr | fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections |
title_full_unstemmed | fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections |
title_short | fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections |
title_sort | fmri resting slow fluctuations correlate with the activity of fast cortico-cortical physiological connections |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527573/ https://www.ncbi.nlm.nih.gov/pubmed/23285136 http://dx.doi.org/10.1371/journal.pone.0052660 |
work_keys_str_mv | AT kochgiacomo fmrirestingslowfluctuationscorrelatewiththeactivityoffastcorticocorticalphysiologicalconnections AT bozzalimarco fmrirestingslowfluctuationscorrelatewiththeactivityoffastcorticocorticalphysiologicalconnections AT bonnisonia fmrirestingslowfluctuationscorrelatewiththeactivityoffastcorticocorticalphysiologicalconnections AT giacobbeviola fmrirestingslowfluctuationscorrelatewiththeactivityoffastcorticocorticalphysiologicalconnections AT caltagironecarlo fmrirestingslowfluctuationscorrelatewiththeactivityoffastcorticocorticalphysiologicalconnections AT cercignanimara fmrirestingslowfluctuationscorrelatewiththeactivityoffastcorticocorticalphysiologicalconnections |