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Neuropeptide GPCRs in C. elegans
Like most organisms, the nematode Caenorhabditis elegans relies heavily on neuropeptidergic signaling. This tiny animal represents a suitable model system to study neuropeptidergic signaling networks with single cell resolution due to the availability of powerful molecular and genetic tools. The ava...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527849/ https://www.ncbi.nlm.nih.gov/pubmed/23267347 http://dx.doi.org/10.3389/fendo.2012.00167 |
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author | Frooninckx, Lotte Van Rompay, Liesbeth Temmerman, Liesbet Van Sinay, Elien Beets, Isabel Janssen, Tom Husson, Steven J. Schoofs, Liliane |
author_facet | Frooninckx, Lotte Van Rompay, Liesbeth Temmerman, Liesbet Van Sinay, Elien Beets, Isabel Janssen, Tom Husson, Steven J. Schoofs, Liliane |
author_sort | Frooninckx, Lotte |
collection | PubMed |
description | Like most organisms, the nematode Caenorhabditis elegans relies heavily on neuropeptidergic signaling. This tiny animal represents a suitable model system to study neuropeptidergic signaling networks with single cell resolution due to the availability of powerful molecular and genetic tools. The availability of the worm’s complete genome sequence allows researchers to browse through it, uncovering putative neuropeptides and their cognate G protein-coupled receptors (GPCRs). Many predictions have been made about the number of C. elegans neuropeptide GPCRs. In this review, we report the state of the art of both verified as well as predicted C. elegans neuropeptide GPCRs. The predicted neuropeptide GPCRs are incorporated into the receptor classification system based on their resemblance to orthologous GPCRs in insects and vertebrates. Appointing the natural ligand(s) to each predicted neuropeptide GPCR (receptor deorphanization) is a crucial step during characterization. The development of deorphanization strategies resulted in a significant increase in the knowledge of neuropeptidergic signaling in C. elegans. Complementary localization and functional studies demonstrate that neuropeptides and their GPCRs represent a rich potential source of behavioral variability in C. elegans. Here, we review all neuropeptidergic signaling pathways that so far have been functionally characterized in C. elegans. |
format | Online Article Text |
id | pubmed-3527849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35278492012-12-24 Neuropeptide GPCRs in C. elegans Frooninckx, Lotte Van Rompay, Liesbeth Temmerman, Liesbet Van Sinay, Elien Beets, Isabel Janssen, Tom Husson, Steven J. Schoofs, Liliane Front Endocrinol (Lausanne) Endocrinology Like most organisms, the nematode Caenorhabditis elegans relies heavily on neuropeptidergic signaling. This tiny animal represents a suitable model system to study neuropeptidergic signaling networks with single cell resolution due to the availability of powerful molecular and genetic tools. The availability of the worm’s complete genome sequence allows researchers to browse through it, uncovering putative neuropeptides and their cognate G protein-coupled receptors (GPCRs). Many predictions have been made about the number of C. elegans neuropeptide GPCRs. In this review, we report the state of the art of both verified as well as predicted C. elegans neuropeptide GPCRs. The predicted neuropeptide GPCRs are incorporated into the receptor classification system based on their resemblance to orthologous GPCRs in insects and vertebrates. Appointing the natural ligand(s) to each predicted neuropeptide GPCR (receptor deorphanization) is a crucial step during characterization. The development of deorphanization strategies resulted in a significant increase in the knowledge of neuropeptidergic signaling in C. elegans. Complementary localization and functional studies demonstrate that neuropeptides and their GPCRs represent a rich potential source of behavioral variability in C. elegans. Here, we review all neuropeptidergic signaling pathways that so far have been functionally characterized in C. elegans. Frontiers Media S.A. 2012-12-21 /pmc/articles/PMC3527849/ /pubmed/23267347 http://dx.doi.org/10.3389/fendo.2012.00167 Text en Copyright © 2012 Frooninckx, Van Rompay, Temmerman, Van Sinay, Beets, Janssen, Husson and Schoofs. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Endocrinology Frooninckx, Lotte Van Rompay, Liesbeth Temmerman, Liesbet Van Sinay, Elien Beets, Isabel Janssen, Tom Husson, Steven J. Schoofs, Liliane Neuropeptide GPCRs in C. elegans |
title | Neuropeptide GPCRs in C. elegans |
title_full | Neuropeptide GPCRs in C. elegans |
title_fullStr | Neuropeptide GPCRs in C. elegans |
title_full_unstemmed | Neuropeptide GPCRs in C. elegans |
title_short | Neuropeptide GPCRs in C. elegans |
title_sort | neuropeptide gpcrs in c. elegans |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527849/ https://www.ncbi.nlm.nih.gov/pubmed/23267347 http://dx.doi.org/10.3389/fendo.2012.00167 |
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