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Structural and Functional Characterization of the Kindlin-1 Pleckstrin Homology Domain

Inside-out activation of integrins is mediated via the binding of talin and kindlin to integrin β-subunit cytoplasmic tails. The kindlin FERM domain is interrupted by a pleckstrin homology (PH) domain within its F2 subdomain. Here, we present data confirming the importance of the kindlin-1 PH domain...

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Detalles Bibliográficos
Autores principales:	Yates, Luke A., Lumb, Craig N., Brahme, Nina N., Zalyte, Ruta, Bird, Louise E., De Colibus, Luigi, Owens, Raymond J., Calderwood, David A., Sansom, Mark S. P., Gilbert, Robert J. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527912/ https://www.ncbi.nlm.nih.gov/pubmed/23132860 http://dx.doi.org/10.1074/jbc.M112.422089

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