Furin-cleaved Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Active and Modulates Low Density Lipoprotein Receptor and Serum Cholesterol Levels

Proprotein convertase subtilisin/kexin 9 (PCSK9) regulates plasma LDL cholesterol levels by regulating the degradation of LDL receptors. Another proprotein convertase, furin, cleaves PCSK9 at Arg(218)-Gln(219) in the surface-exposed “218 loop.” This cleaved form circulates in blood along with the in...

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Detalles Bibliográficos
Autores principales: Lipari, Michael T., Li, Wei, Moran, Paul, Kong-Beltran, Monica, Sai, Tao, Lai, Joyce, Lin, S. Jack, Kolumam, Ganesh, Zavala-Solorio, Jose, Izrael-Tomasevic, Anita, Arnott, David, Wang, Jianyong, Peterson, Andrew S., Kirchhofer, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527935/
https://www.ncbi.nlm.nih.gov/pubmed/23135270
http://dx.doi.org/10.1074/jbc.M112.380618

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