Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives

Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available α-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The...

Descripción completa

Detalles Bibliográficos
Autores principales: Kouznetsov, Vladímir V., Zacchino, Susana A., Sortino, Maximiliano, Vargas Méndez, Leonor Y., Gupta, Mahabir P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528049/
https://www.ncbi.nlm.nih.gov/pubmed/23264936
http://dx.doi.org/10.3797/scipharm.1209-03
_version_ 1782253786355466240
author Kouznetsov, Vladímir V.
Zacchino, Susana A.
Sortino, Maximiliano
Vargas Méndez, Leonor Y.
Gupta, Mahabir P.
author_facet Kouznetsov, Vladímir V.
Zacchino, Susana A.
Sortino, Maximiliano
Vargas Méndez, Leonor Y.
Gupta, Mahabir P.
author_sort Kouznetsov, Vladímir V.
collection PubMed
description Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available α-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC(50) < 10 μg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-naphthalen-1-amines resulted in activity against (MIC 25–32 μg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.
format Online
Article
Text
id pubmed-3528049
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Österreichische Apotheker-Verlagsgesellschaft
record_format MEDLINE/PubMed
spelling pubmed-35280492012-12-21 Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives Kouznetsov, Vladímir V. Zacchino, Susana A. Sortino, Maximiliano Vargas Méndez, Leonor Y. Gupta, Mahabir P. Sci Pharm Research Article Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available α-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC(50) < 10 μg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-naphthalen-1-amines resulted in activity against (MIC 25–32 μg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes. Österreichische Apotheker-Verlagsgesellschaft 2012 2012-10-23 /pmc/articles/PMC3528049/ /pubmed/23264936 http://dx.doi.org/10.3797/scipharm.1209-03 Text en © Kouznetsov et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kouznetsov, Vladímir V.
Zacchino, Susana A.
Sortino, Maximiliano
Vargas Méndez, Leonor Y.
Gupta, Mahabir P.
Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
title Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
title_full Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
title_fullStr Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
title_full_unstemmed Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
title_short Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
title_sort cytotoxic and antifungal activities of diverse α-naphthylamine derivatives
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528049/
https://www.ncbi.nlm.nih.gov/pubmed/23264936
http://dx.doi.org/10.3797/scipharm.1209-03
work_keys_str_mv AT kouznetsovvladimirv cytotoxicandantifungalactivitiesofdiverseanaphthylaminederivatives
AT zacchinosusanaa cytotoxicandantifungalactivitiesofdiverseanaphthylaminederivatives
AT sortinomaximiliano cytotoxicandantifungalactivitiesofdiverseanaphthylaminederivatives
AT vargasmendezleonory cytotoxicandantifungalactivitiesofdiverseanaphthylaminederivatives
AT guptamahabirp cytotoxicandantifungalactivitiesofdiverseanaphthylaminederivatives

Ejemplares similares