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Decreased Hippocampal 5-HT and DA Levels Following Sub-Chronic Exposure to Noise Stress: Impairment in both Spatial and Recognition Memory in Male Rats

Mankind is exposed to a number of stressors, and among them noise is one which can cause intense stress. High levels of background noise can severely impair one’s ability to concentrate. The present study was aimed to investigate the effect of sub-chronic noise stress on cognitive behavior and hippo...

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Autores principales: Haider, Saida, Naqvi, Fizza, Batool, Zehra, Tabassum, Saiqa, Perveen, Tahira, Saleem, Sadia, Haleem, Darakhshan Jabeen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528056/
https://www.ncbi.nlm.nih.gov/pubmed/23264946
http://dx.doi.org/10.3797/scipharm.1207-15
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author Haider, Saida
Naqvi, Fizza
Batool, Zehra
Tabassum, Saiqa
Perveen, Tahira
Saleem, Sadia
Haleem, Darakhshan Jabeen
author_facet Haider, Saida
Naqvi, Fizza
Batool, Zehra
Tabassum, Saiqa
Perveen, Tahira
Saleem, Sadia
Haleem, Darakhshan Jabeen
author_sort Haider, Saida
collection PubMed
description Mankind is exposed to a number of stressors, and among them noise is one which can cause intense stress. High levels of background noise can severely impair one’s ability to concentrate. The present study was aimed to investigate the effect of sub-chronic noise stress on cognitive behavior and hippocampal monoamine levels in male rats. The study was performed on 12 male Wistar rats, divided into two groups; the control and noise-exposed. The rats in the test group were subjected to noise stress, 4h daily for 15 days. Cognitive testing was performed by the Elevated Plus Maze test (EPM) and Novel Object Recognition test (NOR). HPLC-EC was used to determine hippocampal monoamine levels and their metabolites. The data obtained revealed a significant decrease in hippocampal serotonin (5-hydroxytryptamine; 5-HT) and dopamine (DA) levels, whereas turnover ratios of 5-HT and DA were significantly increased compared to the controls. Rats exposed to noise exhibited a significant decrement in spatial memory. A significantly decreased recognition index of rats exposed to noise as compared to the control was also observed in the NOR test. Results of the present findings suggest the role of decreased hippocampal 5-HT and DA in the impairment of cognitive function following noise exposure.
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spelling pubmed-35280562012-12-21 Decreased Hippocampal 5-HT and DA Levels Following Sub-Chronic Exposure to Noise Stress: Impairment in both Spatial and Recognition Memory in Male Rats Haider, Saida Naqvi, Fizza Batool, Zehra Tabassum, Saiqa Perveen, Tahira Saleem, Sadia Haleem, Darakhshan Jabeen Sci Pharm Research Article Mankind is exposed to a number of stressors, and among them noise is one which can cause intense stress. High levels of background noise can severely impair one’s ability to concentrate. The present study was aimed to investigate the effect of sub-chronic noise stress on cognitive behavior and hippocampal monoamine levels in male rats. The study was performed on 12 male Wistar rats, divided into two groups; the control and noise-exposed. The rats in the test group were subjected to noise stress, 4h daily for 15 days. Cognitive testing was performed by the Elevated Plus Maze test (EPM) and Novel Object Recognition test (NOR). HPLC-EC was used to determine hippocampal monoamine levels and their metabolites. The data obtained revealed a significant decrease in hippocampal serotonin (5-hydroxytryptamine; 5-HT) and dopamine (DA) levels, whereas turnover ratios of 5-HT and DA were significantly increased compared to the controls. Rats exposed to noise exhibited a significant decrement in spatial memory. A significantly decreased recognition index of rats exposed to noise as compared to the control was also observed in the NOR test. Results of the present findings suggest the role of decreased hippocampal 5-HT and DA in the impairment of cognitive function following noise exposure. Österreichische Apotheker-Verlagsgesellschaft 2012 2012-10-07 /pmc/articles/PMC3528056/ /pubmed/23264946 http://dx.doi.org/10.3797/scipharm.1207-15 Text en © Haider et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Haider, Saida
Naqvi, Fizza
Batool, Zehra
Tabassum, Saiqa
Perveen, Tahira
Saleem, Sadia
Haleem, Darakhshan Jabeen
Decreased Hippocampal 5-HT and DA Levels Following Sub-Chronic Exposure to Noise Stress: Impairment in both Spatial and Recognition Memory in Male Rats
title Decreased Hippocampal 5-HT and DA Levels Following Sub-Chronic Exposure to Noise Stress: Impairment in both Spatial and Recognition Memory in Male Rats
title_full Decreased Hippocampal 5-HT and DA Levels Following Sub-Chronic Exposure to Noise Stress: Impairment in both Spatial and Recognition Memory in Male Rats
title_fullStr Decreased Hippocampal 5-HT and DA Levels Following Sub-Chronic Exposure to Noise Stress: Impairment in both Spatial and Recognition Memory in Male Rats
title_full_unstemmed Decreased Hippocampal 5-HT and DA Levels Following Sub-Chronic Exposure to Noise Stress: Impairment in both Spatial and Recognition Memory in Male Rats
title_short Decreased Hippocampal 5-HT and DA Levels Following Sub-Chronic Exposure to Noise Stress: Impairment in both Spatial and Recognition Memory in Male Rats
title_sort decreased hippocampal 5-ht and da levels following sub-chronic exposure to noise stress: impairment in both spatial and recognition memory in male rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528056/
https://www.ncbi.nlm.nih.gov/pubmed/23264946
http://dx.doi.org/10.3797/scipharm.1207-15
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